exRNAdisease

Entry Detail

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General Information

Database ID: exR0087355 RNA Name: hsa-miR-24-3p RNA Type: miRNA Chromosome: chr9 Starnd: + Coordinate: Start Site(bp): 95086064 End Site(bp): 95086085 External Links: hsa-miR-24-3p

Disease Information

Disease Name: Moyamoya Disease Disease Category: Nervous System Diseases MeSH ID: D009072 Type: Diseases Category/Nervous System Diseases Alias: Progressive Intracranial Occlusive Arteropathy (Moyamoya)//Moyamoya Syndrome//Moya-Moya Disease//Disease, Moya-Moya//Moya Moya Disease//Cerebrovascular Moyamoya Disease//Moyamoya Disease, Primary//Disease, Primary Moyamoya//Moyamoya Diseases, Primary//Primary Moyamoya Disease//Primary Moyamoya Diseases//Moyamoya Disease, Classic//Classic Moyamoya Disease//Disease, Classic Moyamoya//Moyamoya Disease, Secondary//Secondary Moyamoya Disease

Expression Detail

GEO ID: GSE100488 Description: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins Experimental Design: Disease vs Control Case Disease Type: Moyamoya Disease Case Disease SubType: NA Case Sample: Moyamoya Disease Control Sample: Normal Number of Case: 11 Number of Control: 10 Number of Samples: 21

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AEN chr15 88621337 88632281 + AMOTL2 chr3 134355874 134375479 - APPL2 chr12 105173297 105236203 - ARPP19 chr15 52547045 52569883 - CD74 chr5 150400041 150412929 - CEP170B chr14 104865268 104896770 + CGN chr1 151510510 151538692 + CPA4 chr7 130293134 130324180 + CREG1 chr1 167529117 167553805 - CYB5B chr16 69424619 69466264 + DNAJB6 chr7 157335381 157417439 + GALNT10 chr5 154190730 154420984 + GIGYF1 chr7 100679507 100694037 - PLEKHM1 chr17 45435900 45490749 - RUBCN chr3 197668867 197749727 - STK4 chr20 44966479 45080021 + TMEM9 chr1 201134772 201171574 - WDR36 chr5 111091716 111130502 + GSK3B chr3 119821323 120094417 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000402 chr12 53670403 53671011 + hsa_circ_0000155 chr1 168007608 168014465 + hsa_circ_0000733 chr17 1561546 1562030 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand A1BG-AS1 chr19 58347718 58355455 + AC005034.3 chr2 75697583 75697996 + AC005394.2 chr19 28435388 28727680 - AC027031.2 chr8 106270144 106272902 + AC079781.5 chr7 97851688 97972985 - AC091564.7 chr11 6610883 6616594 - AL031282.2 chr1 1702736 1737688 - DIO3OS chr14 101552221 101560431 - EBLN3P chr9 37079645 37090928 + KCNQ1OT1 chr11 2608328 2699994 - MCM3AP-AS1 chr21 46229196 46259390 + MIR22HG chr17 1711493 1717174 - MIR497HG chr17 7015818 7019659 - NEAT1 chr11 65422774 65445540 + Display:

Experiment Detail

GEO ID: GSE100488 Sample Source: Blood Source Fraction: Plasma Platform: GPL20712 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 291 Sample treatment protocol: Whole blood samples were collected into disodium ethylenediaminotetraacetate tubes, centrifuged (4 °C, 3000 rpm, 30 minutes) immediately for plasma. RNA Extract protocol: Total RNA was isolated from 200 uL of the pooled plasma using miRNeasy Serum/Plasma Kit (QIAGEN, Hilden, Germany). RNA library preparation protocol: Cyanine 3-pCp-labeled microRNA was prepared from 2-uL of total RNA isolated from 200-uL of plasma, using Agilent's miRNA Complete Labeling and Hyb Kit (part number 5190-0456).

Reference

PMID: 30157848 Title: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins and endothelial microRNA expression analysis using iPS cell line Author: Uchino H, Ito M, Kazumata K, Hama Y, Hamauchi S, Terasaka S, Sasaki H, Houkin K Journal: BMC Med Genomics. 2018 Aug 29;11(1):72. Description: we employed a disease discordant monozygotic twin-based study design to unmask potential confounders.