exRNAdisease

Entry Detail

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General Information

Database ID: exR0087389 RNA Name: hsa-miR-423-5p RNA Type: miRNA Chromosome: chr17 Starnd: + Coordinate: Start Site(bp): 30117095 End Site(bp): 30117117 External Links: hsa-miR-423-5p

Disease Information

Disease Name: Moyamoya Disease Disease Category: Nervous System Diseases MeSH ID: D009072 Type: Diseases Category/Nervous System Diseases Alias: Progressive Intracranial Occlusive Arteropathy (Moyamoya)//Moyamoya Syndrome//Moya-Moya Disease//Disease, Moya-Moya//Moya Moya Disease//Cerebrovascular Moyamoya Disease//Moyamoya Disease, Primary//Disease, Primary Moyamoya//Moyamoya Diseases, Primary//Primary Moyamoya Disease//Primary Moyamoya Diseases//Moyamoya Disease, Classic//Classic Moyamoya Disease//Disease, Classic Moyamoya//Moyamoya Disease, Secondary//Secondary Moyamoya Disease

Expression Detail

GEO ID: GSE100488 Description: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins Experimental Design: Disease vs Control Case Disease Type: Moyamoya Disease Case Disease SubType: NA Case Sample: Moyamoya Disease Control Sample: Normal Number of Case: 11 Number of Control: 10 Number of Samples: 21

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand DCAF7 chr17 63550477 63594279 + PGAM1 chr10 97426191 97433444 + MINK1 chr17 4833340 4898061 + PSME3 chr17 42824385 42843760 + LIMD2 chr17 63695888 63701172 - SYVN1 chr11 65121780 65134533 - KLC2 chr11 66257294 66267860 + MYBL2 chr20 43667019 43716495 + DLGAP4 chr20 36306336 36528637 + CAPN15 chr16 527712 554636 + MAPKBP1 chr15 41774434 41827855 + PAK2 chr3 196739857 196832647 + ACTN4 chr19 38647649 38731589 + C1QTNF6 chr22 37180166 37199385 - MAPK8IP2 chr22 50600793 50613981 + BCORL1 chrX 129981107 130058083 + FAM83H chr8 143723933 143738234 - WDR45B chr17 82614562 82648553 - CDCA7 chr2 173354820 173368997 + PRR12 chr19 49591182 49626439 + CHP1 chr15 41230839 41281887 + TNFAIP3 chr6 137867214 137883312 + IL2RB chr22 37125843 37175054 - RAB8A chr19 16111889 16134234 + HNRNPA2B1 chr7 26173057 26201529 - ATN1 chr12 6924463 6942321 + EIF5AL1 chr10 79512601 79516440 + IGF2BP1 chr17 48997385 49056145 + PPDPF chr20 63520765 63522206 + CTSD chr11 1752755 1764573 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0001472 chr5 36953719 36976504 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009133.5 chr16 29808679 29812227 + AC016876.2 chr17 7581964 7584086 - AC021078.1 chr5 149494314 149504670 - AL356488.2 chr1 109100193 109100619 + H19 chr11 1995176 2001470 - KCNQ1OT1 chr11 2608328 2699994 - MIR663AHG chr20 26167817 26251546 - MIRLET7BHG chr22 46053869 46113928 + NEAT1 chr11 65422774 65445540 + STAG3L5P-PVRIG2P-PILRB chr7 100336104 100367831 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE100488 Sample Source: Blood Source Fraction: Plasma Platform: GPL20712 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 291 Sample treatment protocol: Whole blood samples were collected into disodium ethylenediaminotetraacetate tubes, centrifuged (4 °C, 3000 rpm, 30 minutes) immediately for plasma. RNA Extract protocol: Total RNA was isolated from 200 uL of the pooled plasma using miRNeasy Serum/Plasma Kit (QIAGEN, Hilden, Germany). RNA library preparation protocol: Cyanine 3-pCp-labeled microRNA was prepared from 2-uL of total RNA isolated from 200-uL of plasma, using Agilent's miRNA Complete Labeling and Hyb Kit (part number 5190-0456).

Reference

PMID: 30157848 Title: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins and endothelial microRNA expression analysis using iPS cell line Author: Uchino H, Ito M, Kazumata K, Hama Y, Hamauchi S, Terasaka S, Sasaki H, Houkin K Journal: BMC Med Genomics. 2018 Aug 29;11(1):72. Description: we employed a disease discordant monozygotic twin-based study design to unmask potential confounders.