exRNAdisease

Entry Detail

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General Information

Database ID: exR0087453 RNA Name: hsa-miR-5100 RNA Type: miRNA Chromosome: chr10 Starnd: + Coordinate: Start Site(bp): 42997630 End Site(bp): 42997651 External Links: hsa-miR-5100

Disease Information

Disease Name: Moyamoya Disease Disease Category: Nervous System Diseases MeSH ID: D009072 Type: Diseases Category/Nervous System Diseases Alias: Progressive Intracranial Occlusive Arteropathy (Moyamoya)//Moyamoya Syndrome//Moya-Moya Disease//Disease, Moya-Moya//Moya Moya Disease//Cerebrovascular Moyamoya Disease//Moyamoya Disease, Primary//Disease, Primary Moyamoya//Moyamoya Diseases, Primary//Primary Moyamoya Disease//Primary Moyamoya Diseases//Moyamoya Disease, Classic//Classic Moyamoya Disease//Disease, Classic Moyamoya//Moyamoya Disease, Secondary//Secondary Moyamoya Disease

Expression Detail

GEO ID: GSE100488 Description: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins Experimental Design: Disease vs Control Case Disease Type: Moyamoya Disease Case Disease SubType: NA Case Sample: Moyamoya Disease Control Sample: Normal Number of Case: 11 Number of Control: 10 Number of Samples: 21

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand SNU13 chr22 41673933 41690504 - GHITM chr10 84139509 84153568 + AGRN chr1 1020120 1056118 + PRRC2B chr9 131373636 131500197 + HNRNPH1 chr5 179614178 179634784 - GTF3C4 chr9 132670035 132694953 + PPCDC chr15 75023586 75117462 + SLC35B1 chr17 49700934 49709014 - SRP72 chr4 56467617 56503681 + SRPK1 chr6 35832966 35921342 - CHPF chr2 219538948 219543809 - NOP14 chr4 2937933 2963406 - SLC52A2 chr8 144354135 144361272 + THOP1 chr19 2785503 2815807 + MACF1 chr1 39081316 39487177 + CPTP chr1 1324756 1328896 + UBR4 chr1 19074510 19210266 - ZNF136 chr19 12163064 12189871 + HCN1 chr5 45254948 45696498 - NUP93 chr16 56730118 56850286 + KCTD2 chr17 75032575 75065889 + NIN chr14 50719763 50831121 - KDSR chr18 63327726 63367228 - ATP1A1 chr1 116372668 116410261 + PRMT6 chr1 107056674 107067636 + FLNA chrX 154348524 154374638 - NUP107 chr12 68686951 68745809 + P4HTM chr3 48989889 49007153 + VSIG10 chr12 118063593 118136026 - WASF2 chr1 27404230 27490167 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand POLR2J4 chr7 43940895 44019175 - SNHG3 chr1 28505980 28510892 + AC008738.2 chr19 33305036 33309387 + Display:

Experiment Detail

GEO ID: GSE100488 Sample Source: Blood Source Fraction: Plasma Platform: GPL20712 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 291 Sample treatment protocol: Whole blood samples were collected into disodium ethylenediaminotetraacetate tubes, centrifuged (4 °C, 3000 rpm, 30 minutes) immediately for plasma. RNA Extract protocol: Total RNA was isolated from 200 uL of the pooled plasma using miRNeasy Serum/Plasma Kit (QIAGEN, Hilden, Germany). RNA library preparation protocol: Cyanine 3-pCp-labeled microRNA was prepared from 2-uL of total RNA isolated from 200-uL of plasma, using Agilent's miRNA Complete Labeling and Hyb Kit (part number 5190-0456).

Reference

PMID: 30157848 Title: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins and endothelial microRNA expression analysis using iPS cell line Author: Uchino H, Ito M, Kazumata K, Hama Y, Hamauchi S, Terasaka S, Sasaki H, Houkin K Journal: BMC Med Genomics. 2018 Aug 29;11(1):72. Description: we employed a disease discordant monozygotic twin-based study design to unmask potential confounders.