exRNAdisease

Entry Detail

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General Information

Database ID: exR0087454 RNA Name: hsa-miR-513a-5p RNA Type: miRNA Chromosome: chrX Starnd: - Coordinate: Start Site(bp): 147213538 End Site(bp): 147213555 External Links: hsa-miR-513a-5p

Disease Information

Disease Name: Moyamoya Disease Disease Category: Nervous System Diseases MeSH ID: D009072 Type: Diseases Category/Nervous System Diseases Alias: Progressive Intracranial Occlusive Arteropathy (Moyamoya)//Moyamoya Syndrome//Moya-Moya Disease//Disease, Moya-Moya//Moya Moya Disease//Cerebrovascular Moyamoya Disease//Moyamoya Disease, Primary//Disease, Primary Moyamoya//Moyamoya Diseases, Primary//Primary Moyamoya Disease//Primary Moyamoya Diseases//Moyamoya Disease, Classic//Classic Moyamoya Disease//Disease, Classic Moyamoya//Moyamoya Disease, Secondary//Secondary Moyamoya Disease

Expression Detail

GEO ID: GSE100488 Description: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins Experimental Design: Disease vs Control Case Disease Type: Moyamoya Disease Case Disease SubType: NA Case Sample: Moyamoya Disease Control Sample: Normal Number of Case: 11 Number of Control: 10 Number of Samples: 21

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AEN chr15 88621337 88632281 + CD276 chr15 73683966 73714514 + FAM168B chr2 131047876 131093460 - GIPC1 chr19 14477760 14496149 - IGF2BP3 chr7 23310209 23470491 - ILF3 chr19 10654261 10692417 + JRK chr8 142657460 142681968 - KCTD21 chr11 78171249 78188626 - KIAA0232 chr4 6781375 6884170 + MET chr7 116672196 116798386 + MTCL1 chr18 8705661 8832778 + NRBP1 chr2 27427790 27442259 + PA2G4 chr12 56104537 56113910 + PAK1 chr11 77321707 77474635 - PLK2 chr5 58453982 58460139 - PPP1CC chr12 110719680 110742939 - PRLR chr5 35048756 35230487 - RHOU chr1 228735479 228746664 + SNX27 chr1 151612006 151699091 + SOX11 chr2 5692384 5701385 + SS18 chr18 26016253 26091217 - STRBP chr9 123109500 123268586 - TMX4 chr20 7977346 8019805 - TXN2 chr22 36467046 36481640 - WASL chr7 123681943 123749003 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000894 chr19 12825634 12826553 - hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0001005 chr2 53921020 53978078 - hsa_circ_0001168 chr20 47691321 47707559 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009133.5 chr16 29808679 29812227 + AC023509.1 chr12 53441741 53467528 + AC095055.1 chr4 151139991 151141103 + AC239868.1 chr1 149861271 149862504 + CYTOR chr2 87454781 87636740 + KCNQ1OT1 chr11 2608328 2699994 - LINC01578 chr15 92819540 92899701 + MIR4435-2HG chr2 111006015 111523376 - MIR663AHG chr20 26167817 26251546 - NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + SNHG16 chr17 76557764 76565348 + SNHG20 chr17 77086716 77099902 + Display:

Experiment Detail

GEO ID: GSE100488 Sample Source: Blood Source Fraction: Plasma Platform: GPL20712 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 291 Sample treatment protocol: Whole blood samples were collected into disodium ethylenediaminotetraacetate tubes, centrifuged (4 °C, 3000 rpm, 30 minutes) immediately for plasma. RNA Extract protocol: Total RNA was isolated from 200 uL of the pooled plasma using miRNeasy Serum/Plasma Kit (QIAGEN, Hilden, Germany). RNA library preparation protocol: Cyanine 3-pCp-labeled microRNA was prepared from 2-uL of total RNA isolated from 200-uL of plasma, using Agilent's miRNA Complete Labeling and Hyb Kit (part number 5190-0456).

Reference

PMID: 30157848 Title: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins and endothelial microRNA expression analysis using iPS cell line Author: Uchino H, Ito M, Kazumata K, Hama Y, Hamauchi S, Terasaka S, Sasaki H, Houkin K Journal: BMC Med Genomics. 2018 Aug 29;11(1):72. Description: we employed a disease discordant monozygotic twin-based study design to unmask potential confounders.