exRNAdisease

Entry Detail

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General Information

Database ID: exR0087504 RNA Name: hsa-miR-6763-5p RNA Type: miRNA Chromosome: chr12 Starnd: + Coordinate: Start Site(bp): 132582002 End Site(bp): 132582020 External Links: hsa-miR-6763-5p

Disease Information

Disease Name: Moyamoya Disease Disease Category: Nervous System Diseases MeSH ID: D009072 Type: Diseases Category/Nervous System Diseases Alias: Progressive Intracranial Occlusive Arteropathy (Moyamoya)//Moyamoya Syndrome//Moya-Moya Disease//Disease, Moya-Moya//Moya Moya Disease//Cerebrovascular Moyamoya Disease//Moyamoya Disease, Primary//Disease, Primary Moyamoya//Moyamoya Diseases, Primary//Primary Moyamoya Disease//Primary Moyamoya Diseases//Moyamoya Disease, Classic//Classic Moyamoya Disease//Disease, Classic Moyamoya//Moyamoya Disease, Secondary//Secondary Moyamoya Disease

Expression Detail

GEO ID: GSE100488 Description: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins Experimental Design: Disease vs Control Case Disease Type: Moyamoya Disease Case Disease SubType: NA Case Sample: Moyamoya Disease Control Sample: Normal Number of Case: 11 Number of Control: 10 Number of Samples: 21

Regulatory Relationship

mRNA targets: NA miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000128 chr1 151139409 151139890 + hsa_circ_0000744 chr17 15968183 15971435 - hsa_circ_0001146 chr20 34241449 34246936 - hsa_circ_0000799 chr17 65941524 65972074 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC008738.7 chr19 33207129 33207639 + AC016876.2 chr17 7581964 7584086 - AC021078.1 chr5 149494314 149504670 - AC023509.1 chr12 53441741 53467528 + AC234582.1 chr1 155195004 155205495 + DSCAM-AS1 chr21 40383083 40385358 + H19 chr11 1995176 2001470 - KCNQ1OT1 chr11 2608328 2699994 - MALAT1 chr11 65497688 65506516 + MEG3 chr14 100779410 100861031 + NEAT1 chr11 65422774 65445540 + STAG3L5P-PVRIG2P-PILRB chr7 100336104 100367831 + VPS9D1-AS1 chr16 89711856 89718165 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE100488 Sample Source: Blood Source Fraction: Plasma Platform: GPL20712 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 291 Sample treatment protocol: Whole blood samples were collected into disodium ethylenediaminotetraacetate tubes, centrifuged (4 °C, 3000 rpm, 30 minutes) immediately for plasma. RNA Extract protocol: Total RNA was isolated from 200 uL of the pooled plasma using miRNeasy Serum/Plasma Kit (QIAGEN, Hilden, Germany). RNA library preparation protocol: Cyanine 3-pCp-labeled microRNA was prepared from 2-uL of total RNA isolated from 200-uL of plasma, using Agilent's miRNA Complete Labeling and Hyb Kit (part number 5190-0456).

Reference

PMID: 30157848 Title: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins and endothelial microRNA expression analysis using iPS cell line Author: Uchino H, Ito M, Kazumata K, Hama Y, Hamauchi S, Terasaka S, Sasaki H, Houkin K Journal: BMC Med Genomics. 2018 Aug 29;11(1):72. Description: we employed a disease discordant monozygotic twin-based study design to unmask potential confounders.