exRNAdisease

Entry Detail

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General Information

Database ID: exR0092956 RNA Name: hsa-miR-1224-5p RNA Type: miRNA Chromosome: chr3 Starnd: + Coordinate: Start Site(bp): 184241405 End Site(bp): 184241423 External Links: hsa-miR-1224-5p

Disease Information

Disease Name: Benign Ovarian Disease Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D010049 Type: Diseases Category/Female Urogenital Diseases and Pregnancy Complications Alias: Ovarian Diseases//Disease, Ovarian//Diseases, Ovarian//Ovarian Disease

Expression Detail

GEO ID: GSE106817 Description: Integrated extracellular microRNA profiling for ovarian cancer screening Experimental Design: Cancer vs Control Case Disease Type: Benign Ovarian Disease Case Disease SubType: NA Case Sample: Benign Ovarian Disease Control Sample: Non-Cancer Number of Case: 29 Number of Control: 2759 Number of Samples: 2788

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ARF3 chr12 48935723 48957487 - DHCR7 chr11 71428193 71452868 - ZNF621 chr3 40524878 40574685 + SEC14L1 chr17 77088749 77217101 + EMC10 chr19 50476400 50490870 + RACGAP1 chr12 49976923 50033136 - THBD chr20 23045633 23049672 - ENSA chr1 150600851 150629612 - SLC9A3R1 chr17 74748628 74769353 + STK4 chr20 44966479 45080021 + LDOC1 chrX 141111605 141177129 - UBL5 chr19 9827892 9830115 + HOXB8 chr17 48611377 48615292 - ANKRD52 chr12 56237807 56258384 - TRAM2 chr6 52497408 52577060 - RNF157 chr17 76142465 76240493 - STC1 chr8 23841929 23854806 - LMBR1 chr7 156668946 156893216 - CALU chr7 128739292 128773400 + ATP6V1A chr3 113747033 113812056 + KIAA1522 chr1 32741830 32774970 + IKBKB chr8 42271302 42332653 + XPO7 chr8 21919662 22006585 + MIER3 chr5 56919602 56971675 - DYRK1B chr19 39825350 39834201 - TBC1D20 chr20 435480 462543 - MAPKAPK2 chr1 206684944 206734283 + OPA3 chr19 45527427 45602212 - AK2 chr1 33007940 33080996 - FYCO1 chr3 45917899 45995824 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009133.5 chr16 29808679 29812227 + AP000766.1 chr11 107312132 107316271 - NEAT1 chr11 65422774 65445540 + TUG1 chr22 30969245 30979395 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE106817 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2535 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30333487 Title: Integrated extracellular microRNA profiling for ovarian cancer screening Author: Yokoi A, Matsuzaki J, Yamamoto Y, Yoneoka Y, Takahashi K, Shimizu H, Uehara T, Ishikawa M, Ikeda SI, Sonoda T, Kawauchi J, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato K, Kato T, Ochiya T Journal: Nat Commun. 2018 Oct 17;9(1):4319. Description: to develop an optimal detection method, we use microarrays to obtain comprehensive miRNA profiles from 4046 serum samples, including 428 patients with ovarian tumors.