Entry Detail


General Information

Database ID:exR0093009
RNA Name:hsa-miR-125b-5p
RNA Type:miRNA
Chromosome:chr21
Starnd:+
Coordinate:
Start Site(bp):16590253End Site(bp):16590274
External Links:hsa-miR-125b-5p



Disease Information

Disease Name:Benign Ovarian Disease
Disease Category:Urogenital Diseases and Pregnancy Complications
MeSH ID:D010049
Type:Diseases Category/Female Urogenital Diseases and Pregnancy Complications
Alias:Ovarian Diseases//Disease, Ovarian//Diseases, Ovarian//Ovarian Disease



Expression Detail

GEO ID:GSE106817
Description:Integrated extracellular microRNA profiling for ovarian cancer screening
Experimental Design:Cancer vs Control
Case Disease Type:Benign Ovarian Disease
Case Disease SubType:NA
Case Sample:Benign Ovarian Disease
Control Sample:Non-Cancer
Number of Case:29
Number of Control:2759
Number of Samples:2788





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
RYBP
chr3
72371825
72446621
-
TRIM65
chr17
75880335
75896951
-
TYSND1
chr10
70137981
70146700
-
UGGT1
chr2
128091200
128195677
+
ZBTB39
chr12
56998836
57006546
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000370
chr11
128628009
128651918
+
hsa_circ_0001723
chr7
91924202
91948826
+
hsa_circ_0001492
chr5
65284462
65290692
+
hsa_circ_0000494
chr13
76134888
76143643
+
hsa_circ_0001307
chr3
51575513
51624575
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC007780.1
chr17
68413623
68524949
+
AC022167.2
chr16
8848105
8860456
+
AC084082.1
chr8
66112667
66126632
+
AC108134.2
chr16
3156736
3157483
-
AC245014.3
chr1
145281116
145281462
+
AL049840.4
chr14
103694516
103695050
-
AL132780.1
chr14
22929607
22956374
+
AL137782.1
chr13
75549773
75807120
+
AL162258.1
chr1
153626332
153634340
-
DANCR
chr4
52712404
52720351
+
KCNQ1OT1
chr11
2608328
2699994
-
NEAT1
chr11
65422774
65445540
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE106817
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21263
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2535
Sample treatment protocol:NA
RNA Extract protocol:Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.).
RNA library preparation protocol:miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.



Reference

PMID:30333487
Title:Integrated extracellular microRNA profiling for ovarian cancer screening
Author:Yokoi A, Matsuzaki J, Yamamoto Y, Yoneoka Y, Takahashi K, Shimizu H, Uehara T, Ishikawa M, Ikeda SI, Sonoda T, Kawauchi J, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato K, Kato T, Ochiya T
Journal:Nat Commun. 2018 Oct 17;9(1):4319.
Description:to develop an optimal detection method, we use microarrays to obtain comprehensive miRNA profiles from 4046 serum samples, including 428 patients with ovarian tumors.