exRNAdisease

Entry Detail

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General Information

Database ID: exR0093028 RNA Name: hsa-miR-1270 RNA Type: miRNA Chromosome: chr19 Starnd: - Coordinate: Start Site(bp): 20399320 End Site(bp): 20399342 External Links: hsa-miR-1270

Disease Information

Disease Name: Benign Ovarian Disease Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D010049 Type: Diseases Category/Female Urogenital Diseases and Pregnancy Complications Alias: Ovarian Diseases//Disease, Ovarian//Diseases, Ovarian//Ovarian Disease

Expression Detail

GEO ID: GSE106817 Description: Integrated extracellular microRNA profiling for ovarian cancer screening Experimental Design: Cancer vs Control Case Disease Type: Benign Ovarian Disease Case Disease SubType: NA Case Sample: Benign Ovarian Disease Control Sample: Non-Cancer Number of Case: 29 Number of Control: 2759 Number of Samples: 2788

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand MIEF1 chr22 39499432 39518132 + WIPF2 chr17 40219304 40284136 + GBA2 chr9 35736866 35749228 - HIF1AN chr10 100529072 100559998 + TCF12 chr15 56918623 57299281 + CDC42EP2 chr11 65314866 65322417 + LITAF chr16 11547722 11636381 - GRHL2 chr8 101492439 101669726 + PRLR chr5 35048756 35230487 - PATL1 chr11 59636716 59669037 - CACNG4 chr17 66964707 67033398 + ZNF652 chr17 49289206 49362473 - CDC37 chr19 10391133 10420121 - AGFG1 chr2 227472152 227561214 + SMG7 chr1 183472216 183598246 + TRIP6 chr7 100867387 100873454 + FN1 chr2 215360440 215436073 - DCBLD2 chr3 98795941 98901695 - BEND3 chr6 107065182 107115269 - NACC1 chr19 13116862 13141147 + TPM4 chr19 16067021 16103002 + TLNRD1 chr15 81000923 81005788 + SRGAP2 chr1 206203345 206464443 + PITPNA chr17 1517718 1562792 - FAM78A chr9 131258076 131276510 - ATP6V1B2 chr8 20197381 20226819 + VGF chr7 101162509 101165569 - PLAGL2 chr20 32192504 32207743 - PCDH10 chr4 133149294 133208606 + B4GALT5 chr20 49632945 49713878 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001247 chr22 46125304 46136418 + hsa_circ_0001159 chr20 40161688 40179999 - hsa_circ_0000471 chr13 33091993 33101669 - hsa_circ_0001666 chr6 170626457 170639638 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC239868.1 chr1 149861271 149862504 + AC245033.4 chr15 82533175 82540008 - AP000233.2 chr21 25095022 25103670 + MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - NR2F2-AS1 chr15 96110040 96327361 - OIP5-AS1 chr15 41283990 41309737 + SNHG12 chr1 28578538 28583132 - SNHG8 chr4 118278709 118285316 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE106817 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2535 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30333487 Title: Integrated extracellular microRNA profiling for ovarian cancer screening Author: Yokoi A, Matsuzaki J, Yamamoto Y, Yoneoka Y, Takahashi K, Shimizu H, Uehara T, Ishikawa M, Ikeda SI, Sonoda T, Kawauchi J, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato K, Kato T, Ochiya T Journal: Nat Commun. 2018 Oct 17;9(1):4319. Description: to develop an optimal detection method, we use microarrays to obtain comprehensive miRNA profiles from 4046 serum samples, including 428 patients with ovarian tumors.