Entry Detail


General Information

Database ID:exR0093114
RNA Name:hsa-miR-140-3p
RNA Type:miRNA
Chromosome:chr16
Starnd:+
Coordinate:
Start Site(bp):69933142End Site(bp):69933162
External Links:hsa-miR-140-3p



Disease Information

Disease Name:Benign Ovarian Disease
Disease Category:Urogenital Diseases and Pregnancy Complications
MeSH ID:D010049
Type:Diseases Category/Female Urogenital Diseases and Pregnancy Complications
Alias:Ovarian Diseases//Disease, Ovarian//Diseases, Ovarian//Ovarian Disease



Expression Detail

GEO ID:GSE106817
Description:Integrated extracellular microRNA profiling for ovarian cancer screening
Experimental Design:Cancer vs Control
Case Disease Type:Benign Ovarian Disease
Case Disease SubType:NA
Case Sample:Benign Ovarian Disease
Control Sample:Non-Cancer
Number of Case:29
Number of Control:2759
Number of Samples:2788





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ARF3
chr12
48935723
48957487
-
ARL1
chr12
101393116
101407772
-
ATP6V0D1
chr16
67438014
67481181
-
CBL
chr11
119206298
119313926
+
CDK6
chr7
92604921
92836594
-
CLASP1
chr2
121337776
121649587
-
CORO1C
chr12
108645109
108731596
-
CRCP
chr7
66114604
66154568
+
CRY2
chr11
45847118
45883248
+
NDST1
chr5
150485818
150558211
+
RNF220
chr1
44405194
44651724
+
SLC31A1
chr9
113221544
113264492
+
TMEM50A
chr1
25338317
25362361
+
ZDHHC6
chr10
112424428
112446917
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000540
chr14
55799534
55821940
+
hsa_circ_0001880
chr9
110084263
110087285
+
hsa_circ_0000943
chr19
47421744
47440665
+
hsa_circ_0000032
chr1
25666964
25669564
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC245014.3
chr1
145281116
145281462
+
AL049840.4
chr14
103694516
103695050
-
AL356488.2
chr1
109100193
109100619
+
KCNQ1OT1
chr11
2608328
2699994
-
MIR17HG
chr13
91347820
91354579
+
MIR29B2CHG
chr1
207801518
207879115
-
MIR497HG
chr17
7015818
7019659
-
MIR663AHG
chr20
26167817
26251546
-
TUG1
chr22
30969245
30979395
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE106817
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21263
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2535
Sample treatment protocol:NA
RNA Extract protocol:Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.).
RNA library preparation protocol:miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.



Reference

PMID:30333487
Title:Integrated extracellular microRNA profiling for ovarian cancer screening
Author:Yokoi A, Matsuzaki J, Yamamoto Y, Yoneoka Y, Takahashi K, Shimizu H, Uehara T, Ishikawa M, Ikeda SI, Sonoda T, Kawauchi J, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato K, Kato T, Ochiya T
Journal:Nat Commun. 2018 Oct 17;9(1):4319.
Description:to develop an optimal detection method, we use microarrays to obtain comprehensive miRNA profiles from 4046 serum samples, including 428 patients with ovarian tumors.