exRNAdisease

Entry Detail

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General Information

Database ID: exR0093125 RNA Name: hsa-miR-145-5p RNA Type: miRNA Chromosome: chr5 Starnd: + Coordinate: Start Site(bp): 149430661 End Site(bp): 149430683 External Links: hsa-miR-145-5p

Disease Information

Disease Name: Benign Ovarian Disease Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D010049 Type: Diseases Category/Female Urogenital Diseases and Pregnancy Complications Alias: Ovarian Diseases//Disease, Ovarian//Diseases, Ovarian//Ovarian Disease

Expression Detail

GEO ID: GSE106817 Description: Integrated extracellular microRNA profiling for ovarian cancer screening Experimental Design: Cancer vs Control Case Disease Type: Benign Ovarian Disease Case Disease SubType: NA Case Sample: Benign Ovarian Disease Control Sample: Non-Cancer Number of Case: 29 Number of Control: 2759 Number of Samples: 2788

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACBD5 chr10 27195214 27242130 - ATP9A chr20 51596514 51768390 - BAZ1B chr7 73440406 73522293 - CARMIL1 chr6 25279078 25620530 + CCNJ chr10 96043394 96060870 + MYRF chr11 61752642 61788518 + PLEKHM1 chr17 45435900 45490749 - PPP1R9B chr17 50133737 50150677 - RAD23B chr9 107283137 107332192 + ZNF28 chr19 52797408 52857600 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001454 chr4 154524454 154533552 + hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0001731 chr7 100731990 100738448 + hsa_circ_0001492 chr5 65284462 65290692 + hsa_circ_0001414 chr4 56277780 56284152 + hsa_circ_0000943 chr19 47421744 47440665 + hsa_circ_0001168 chr20 47691321 47707559 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC006064.5 chr12 6510275 6510522 + AC016876.2 chr17 7581964 7584086 - AC023509.1 chr12 53441741 53467528 + AC105339.2 chr15 82752884 82757208 + AC144548.1 chr12 110387463 110445548 - AL031282.2 chr1 1702736 1737688 - JPX chrX 73944182 74070408 + KCNQ1OT1 chr11 2608328 2699994 - LINC00852 chr3 10284419 10285746 + MALAT1 chr11 65497688 65506516 + MEG3 chr14 100779410 100861031 + SNHG1 chr11 62851984 62855953 - TUG1 chr22 30969245 30979395 + Display:

Experiment Detail

GEO ID: GSE106817 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2535 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30333487 Title: Integrated extracellular microRNA profiling for ovarian cancer screening Author: Yokoi A, Matsuzaki J, Yamamoto Y, Yoneoka Y, Takahashi K, Shimizu H, Uehara T, Ishikawa M, Ikeda SI, Sonoda T, Kawauchi J, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato K, Kato T, Ochiya T Journal: Nat Commun. 2018 Oct 17;9(1):4319. Description: to develop an optimal detection method, we use microarrays to obtain comprehensive miRNA profiles from 4046 serum samples, including 428 patients with ovarian tumors.