exRNAdisease

Entry Detail

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General Information

Database ID: exR0093232 RNA Name: hsa-miR-197-3p RNA Type: miRNA Chromosome: chr1 Starnd: + Coordinate: Start Site(bp): 109598940 End Site(bp): 109598961 External Links: hsa-miR-197-3p

Disease Information

Disease Name: Benign Ovarian Disease Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D010049 Type: Diseases Category/Female Urogenital Diseases and Pregnancy Complications Alias: Ovarian Diseases//Disease, Ovarian//Diseases, Ovarian//Ovarian Disease

Expression Detail

GEO ID: GSE106817 Description: Integrated extracellular microRNA profiling for ovarian cancer screening Experimental Design: Cancer vs Control Case Disease Type: Benign Ovarian Disease Case Disease SubType: NA Case Sample: Benign Ovarian Disease Control Sample: Non-Cancer Number of Case: 29 Number of Control: 2759 Number of Samples: 2788

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand E2F1 chr20 33675477 33686385 - REEP4 chr8 22138020 22141951 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000591 chr15 41961025 41962156 + hsa_circ_0001265 chr3 9711115 9712854 + hsa_circ_0000943 chr19 47421744 47440665 + hsa_circ_0001387 chr4 1902352 1936989 + hsa_circ_0000826 chr18 9182379 9221997 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC135050.6 chr16 31122235 31124064 + MALAT1 chr11 65497688 65506516 + MIR497HG chr17 7015818 7019659 - NEAT1 chr11 65422774 65445540 + TUG1 chr22 30969245 30979395 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE106817 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2535 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30333487 Title: Integrated extracellular microRNA profiling for ovarian cancer screening Author: Yokoi A, Matsuzaki J, Yamamoto Y, Yoneoka Y, Takahashi K, Shimizu H, Uehara T, Ishikawa M, Ikeda SI, Sonoda T, Kawauchi J, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato K, Kato T, Ochiya T Journal: Nat Commun. 2018 Oct 17;9(1):4319. Description: to develop an optimal detection method, we use microarrays to obtain comprehensive miRNA profiles from 4046 serum samples, including 428 patients with ovarian tumors.