exRNAdisease

Entry Detail

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General Information

Database ID: exR0093325 RNA Name: hsa-miR-23a-3p RNA Type: miRNA Chromosome: chr19 Starnd: - Coordinate: Start Site(bp): 13836595 End Site(bp): 13836615 External Links: hsa-miR-23a-3p

Disease Information

Disease Name: Benign Ovarian Disease Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D010049 Type: Diseases Category/Female Urogenital Diseases and Pregnancy Complications Alias: Ovarian Diseases//Disease, Ovarian//Diseases, Ovarian//Ovarian Disease

Expression Detail

GEO ID: GSE106817 Description: Integrated extracellular microRNA profiling for ovarian cancer screening Experimental Design: Cancer vs Control Case Disease Type: Benign Ovarian Disease Case Disease SubType: NA Case Sample: Benign Ovarian Disease Control Sample: Non-Cancer Number of Case: 29 Number of Control: 2759 Number of Samples: 2788

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ADGRG6 chr6 142301854 142446266 + ATAD1 chr10 87751512 87841343 - ATXN7L3 chr17 44191805 44200113 - FKBP5 chr6 35573585 35728583 - GATAD2B chr1 153789030 153923360 - IRF4 chr6 391752 411443 + KLF12 chr13 73686089 73995056 - PHLDA1 chr12 76025447 76033932 - TK2 chr16 66508003 66552544 - TNFAIP3 chr6 137867214 137883312 + TOB2 chr22 41433494 41446801 - USP54 chr10 73497538 73625953 - VAT1 chr17 43014607 43025123 - AC008758.1 chr19 12461559 12551474 - ATP5MD chr10 103389041 103396492 - BACE2 chr21 41167801 41282530 + GSTP1 chr11 67583742 67586656 + ZNF709 chr19 12461184 12513854 - ZNF91 chr19 23304991 23395471 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000384 chr12 27867712 27877119 + hsa_circ_0000711 chr16 68155889 68160513 + hsa_circ_0000881 chr19 5653125 5654467 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007780.1 chr17 68413623 68524949 + AC011503.2 chr19 23927788 23929287 + AC078846.1 chr7 129604548 129611630 - AC091564.7 chr11 6610883 6616594 - AC124068.2 chr15 89335053 89336161 + AC144548.1 chr12 110387463 110445548 - AL035458.2 chr20 34234840 34281173 - GAS5 chr1 173858559 173868882 - MALAT1 chr11 65497688 65506516 + MCM3AP-AS1 chr21 46229196 46259390 + NEAT1 chr11 65422774 65445540 + SNHG16 chr17 76557764 76565348 + SNHG5 chr6 85650491 85678932 - STAG3L5P-PVRIG2P-PILRB chr7 100336104 100367831 + TYMSOS chr18 630886 658340 - XIST chrX 73820649 73852723 - Z93241.1 chr22 42615244 42615907 + ZNF674-AS1 chrX 46545438 46548841 + Display:

Experiment Detail

GEO ID: GSE106817 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2535 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30333487 Title: Integrated extracellular microRNA profiling for ovarian cancer screening Author: Yokoi A, Matsuzaki J, Yamamoto Y, Yoneoka Y, Takahashi K, Shimizu H, Uehara T, Ishikawa M, Ikeda SI, Sonoda T, Kawauchi J, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato K, Kato T, Ochiya T Journal: Nat Commun. 2018 Oct 17;9(1):4319. Description: to develop an optimal detection method, we use microarrays to obtain comprehensive miRNA profiles from 4046 serum samples, including 428 patients with ovarian tumors.