exRNAdisease

Entry Detail

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General Information

Database ID: exR0093360 RNA Name: hsa-miR-29a-3p RNA Type: miRNA Chromosome: chr7 Starnd: - Coordinate: Start Site(bp): 130876748 End Site(bp): 130876769 External Links: hsa-miR-29a-3p

Disease Information

Disease Name: Benign Ovarian Disease Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D010049 Type: Diseases Category/Female Urogenital Diseases and Pregnancy Complications Alias: Ovarian Diseases//Disease, Ovarian//Diseases, Ovarian//Ovarian Disease

Expression Detail

GEO ID: GSE106817 Description: Integrated extracellular microRNA profiling for ovarian cancer screening Experimental Design: Cancer vs Control Case Disease Type: Benign Ovarian Disease Case Disease SubType: NA Case Sample: Benign Ovarian Disease Control Sample: Non-Cancer Number of Case: 29 Number of Control: 2759 Number of Samples: 2788

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AMER1 chrX 64185117 64205708 - APH1A chr1 150265399 150269580 - APP chr21 25880550 26171128 - BIRC5 chr17 78214186 78225636 + C1QTNF6 chr22 37180166 37199385 - CALU chr7 128739292 128773400 + CREG1 chr1 167529117 167553805 - FASN chr17 82078338 82098294 - GATAD2B chr1 153789030 153923360 - KLHDC3 chr6 43014103 43021298 + KMT5C chr19 55339853 55348121 + MAZ chr16 29806106 29811164 + NASP chr1 45583846 45618904 + NMI chr2 151270470 151289894 - PITPNA chr17 1517718 1562792 - RNF138 chr18 32091874 32131561 + RREB1 chr6 7107597 7251980 + SH3GLB1 chr1 86704570 86748184 + SP1 chr12 53380176 53416446 + TET3 chr2 73986404 74108176 + XPO6 chr16 28097979 28211920 - ATP5F1B chr12 56638175 56645984 - RHOH chr4 40191053 40246967 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000018 chr1 15860731 15863309 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007036.3 chr7 30157531 30159534 + AC012146.1 chr17 5111468 5115004 + AC018521.1 chr17 47945424 47981736 + AL137129.1 chr14 61734138 61776260 + AL355488.1 chr1 110370154 110373003 + AL391244.1 chr1 1420245 1422691 + AP001432.1 chr21 37221419 37237744 + H19 chr11 1995176 2001470 - MIR4458HG chr5 8450701 8486930 + MIR497HG chr17 7015818 7019659 - MIRLET7BHG chr22 46053869 46113928 + NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + TUG1 chr22 30969245 30979395 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE106817 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2535 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30333487 Title: Integrated extracellular microRNA profiling for ovarian cancer screening Author: Yokoi A, Matsuzaki J, Yamamoto Y, Yoneoka Y, Takahashi K, Shimizu H, Uehara T, Ishikawa M, Ikeda SI, Sonoda T, Kawauchi J, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato K, Kato T, Ochiya T Journal: Nat Commun. 2018 Oct 17;9(1):4319. Description: to develop an optimal detection method, we use microarrays to obtain comprehensive miRNA profiles from 4046 serum samples, including 428 patients with ovarian tumors.