exRNAdisease

Entry Detail

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General Information

Database ID: exR0093378 RNA Name: hsa-miR-302d-3p RNA Type: miRNA Chromosome: chr4 Starnd: - Coordinate: Start Site(bp): 112648006 End Site(bp): 112648028 External Links: hsa-miR-302d-3p

Disease Information

Disease Name: Benign Ovarian Disease Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D010049 Type: Diseases Category/Female Urogenital Diseases and Pregnancy Complications Alias: Ovarian Diseases//Disease, Ovarian//Diseases, Ovarian//Ovarian Disease

Expression Detail

GEO ID: GSE106817 Description: Integrated extracellular microRNA profiling for ovarian cancer screening Experimental Design: Cancer vs Control Case Disease Type: Benign Ovarian Disease Case Disease SubType: NA Case Sample: Benign Ovarian Disease Control Sample: Non-Cancer Number of Case: 29 Number of Control: 2759 Number of Samples: 2788

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand POLR3G chr5 90471748 90514557 + RPL27 chr17 42998273 43002959 + MSL1 chr17 40121971 40136917 + MGLL chr3 127689062 128052190 - WASF3 chr13 26557683 26688948 + CCNE1 chr19 29811991 29824312 + PPIB chr15 64155812 64163205 - CDK6 chr7 92604921 92836594 - CLOCK chr4 55427903 55546909 - QRICH1 chr3 49029707 49094363 - FBXO5 chr6 152970519 152983579 - VPS35 chr16 46656132 46689518 - PXYLP1 chr3 141228726 141367753 + ATP6V1C1 chr8 103021063 103073051 + FYCO1 chr3 45917899 45995824 - TXNIP chr1 145992435 145996579 - KDM4B chr19 4969113 5153598 + PNPLA8 chr7 108470417 108569666 - AMPD2 chr1 109616104 109632053 + MMD chr17 55392622 55421924 - ZNF608 chr5 124636913 124748807 - PLAGL2 chr20 32192504 32207743 - EPHX1 chr1 225810092 225845563 + COPS5 chr8 67043079 67083783 - MRPS6 chr21 34073224 34143034 + RIT1 chr1 155897808 155911404 - HNRNPH2 chrX 101408222 101414133 + BCLAF1 chr6 136256627 136289851 - BTN3A1 chr6 26402237 26415208 + COL4A2 chr13 110305812 110513209 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000943 chr19 47421744 47440665 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC011503.2 chr19 23927788 23929287 + AL049840.4 chr14 103694516 103695050 - ARHGAP27P1-BPTFP1-KPNA2P3 chr17 64749663 64781707 - FGD5-AS1 chr3 14920347 14948424 - MIR17HG chr13 91347820 91354579 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE106817 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2535 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30333487 Title: Integrated extracellular microRNA profiling for ovarian cancer screening Author: Yokoi A, Matsuzaki J, Yamamoto Y, Yoneoka Y, Takahashi K, Shimizu H, Uehara T, Ishikawa M, Ikeda SI, Sonoda T, Kawauchi J, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato K, Kato T, Ochiya T Journal: Nat Commun. 2018 Oct 17;9(1):4319. Description: to develop an optimal detection method, we use microarrays to obtain comprehensive miRNA profiles from 4046 serum samples, including 428 patients with ovarian tumors.