exRNAdisease

Entry Detail

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General Information

Database ID: exR0093557 RNA Name: hsa-miR-33a-5p RNA Type: miRNA Chromosome: chr22 Starnd: + Coordinate: Start Site(bp): 41900949 End Site(bp): 41900969 External Links: hsa-miR-33a-5p

Disease Information

Disease Name: Benign Ovarian Disease Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D010049 Type: Diseases Category/Female Urogenital Diseases and Pregnancy Complications Alias: Ovarian Diseases//Disease, Ovarian//Diseases, Ovarian//Ovarian Disease

Expression Detail

GEO ID: GSE106817 Description: Integrated extracellular microRNA profiling for ovarian cancer screening Experimental Design: Cancer vs Control Case Disease Type: Benign Ovarian Disease Case Disease SubType: NA Case Sample: Benign Ovarian Disease Control Sample: Non-Cancer Number of Case: 29 Number of Control: 2759 Number of Samples: 2788

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RBM33 chr7 155644451 155781485 + ARCN1 chr11 118572390 118603033 + CROT chr7 87345681 87399795 + PIM1 chr6 37170152 37175428 + BRIP1 chr17 61679139 61863528 - RAB11FIP2 chr10 118004916 118046941 - ECHDC1 chr6 127288712 127343609 - NFAT5 chr16 69565094 69704666 + ZBTB34 chr9 126860665 126885878 + EIF5A2 chr3 170888418 170908644 - XRN1 chr3 142306607 142448062 - WDFY3 chr4 84669610 84966391 - CERK chr22 46684410 46738252 - IGF1R chr15 98648539 98964530 + MYO19 chr17 36495633 36543435 - E2F3 chr6 20401879 20493714 + AFF4 chr5 132875395 132963634 - DDX5 chr17 64498254 64508199 - RCAN1 chr21 34513142 34615113 - GLCCI1 chr7 7968796 8094272 + ROBO1 chr3 78597239 79767998 - RNF11 chr1 51236273 51273447 + AFF3 chr2 99545419 100192428 - ZDHHC9 chrX 129803288 129843909 - ADCY9 chr16 3953387 4116442 - ZFYVE16 chr5 80408013 80483379 + ZNF148 chr3 125225561 125375354 - MAPK1IP1L chr14 55051647 55070194 + CREM chr10 35126791 35212958 + KPNA4 chr3 160495007 160565571 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0001349 chr3 152132729 152150709 + hsa_circ_0000642 chr15 80390757 80415142 + hsa_circ_0000643 chr15 80412669 80415142 + hsa_circ_0000284 chr11 33307958 33309057 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC023509.1 chr12 53441741 53467528 + DANCR chr4 52712404 52720351 + FGD5-AS1 chr3 14920347 14948424 - MCF2L-AS1 chr13 112967484 112968824 - NEAT1 chr11 65422774 65445540 + Display:

Experiment Detail

GEO ID: GSE106817 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2535 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30333487 Title: Integrated extracellular microRNA profiling for ovarian cancer screening Author: Yokoi A, Matsuzaki J, Yamamoto Y, Yoneoka Y, Takahashi K, Shimizu H, Uehara T, Ishikawa M, Ikeda SI, Sonoda T, Kawauchi J, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato K, Kato T, Ochiya T Journal: Nat Commun. 2018 Oct 17;9(1):4319. Description: to develop an optimal detection method, we use microarrays to obtain comprehensive miRNA profiles from 4046 serum samples, including 428 patients with ovarian tumors.