exRNAdisease

Entry Detail

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General Information

Database ID: exR0093614 RNA Name: hsa-miR-3654 RNA Type: miRNA Chromosome: chr7 Starnd: - Coordinate: Start Site(bp): 133034860 End Site(bp): 133034878 External Links: hsa-miR-3654

Disease Information

Disease Name: Benign Ovarian Disease Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D010049 Type: Diseases Category/Female Urogenital Diseases and Pregnancy Complications Alias: Ovarian Diseases//Disease, Ovarian//Diseases, Ovarian//Ovarian Disease

Expression Detail

GEO ID: GSE106817 Description: Integrated extracellular microRNA profiling for ovarian cancer screening Experimental Design: Cancer vs Control Case Disease Type: Benign Ovarian Disease Case Disease SubType: NA Case Sample: Benign Ovarian Disease Control Sample: Non-Cancer Number of Case: 29 Number of Control: 2759 Number of Samples: 2788

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TUBB chr6 30720352 30725426 + DEPDC1B chr5 60596912 60700190 - ERI2 chr16 20780193 20900349 - CCT7 chr2 73233420 73253021 + APLP2 chr11 130068147 130144811 + MRPL11 chr11 66435075 66466738 - HSPA8 chr11 123057489 123063230 - GGH chr8 63015079 63038806 - MDK chr11 46380756 46383837 + EGR1 chr5 138465479 138469303 + MKRN1 chr7 140453033 140479536 - RPS14 chr5 150442635 150449739 - DDTL chr22 23966888 23972556 + DCAF8 chr1 160215715 160262549 - RNPS1 chr16 2253116 2268397 - DCPS chr11 126304060 126350005 + MPRIP chr17 17042545 17217679 + RPL12 chr9 127447674 127451406 - RPL13A chr19 49487554 49492308 + RPS12 chr6 132814569 132817564 + HLA-DRA chr6 32439878 32445046 + STMN1 chr1 25884181 25906991 - RPS3 chr11 75399515 75422280 + RPL3 chr22 39312882 39320389 - FTH1 chr11 61959718 61967634 - TSPAN18 chr11 44726465 44932423 + HLA-DRB5 chr6 32517353 32530287 - NOLC1 chr10 102152176 102163871 + HMGA1 chr6 34236873 34246231 + CCDC85C chr14 99500190 99604207 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AD000090.1 chr19 35557956 35581954 + BCDIN3D-AS1 chr12 49827913 49841143 + LINC00996 chr7 150433654 150448140 + Display:

Experiment Detail

GEO ID: GSE106817 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2535 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30333487 Title: Integrated extracellular microRNA profiling for ovarian cancer screening Author: Yokoi A, Matsuzaki J, Yamamoto Y, Yoneoka Y, Takahashi K, Shimizu H, Uehara T, Ishikawa M, Ikeda SI, Sonoda T, Kawauchi J, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato K, Kato T, Ochiya T Journal: Nat Commun. 2018 Oct 17;9(1):4319. Description: to develop an optimal detection method, we use microarrays to obtain comprehensive miRNA profiles from 4046 serum samples, including 428 patients with ovarian tumors.