Entry Detail


General Information

Database ID:exR0093884
RNA Name:hsa-miR-4426
RNA Type:miRNA
Chromosome:chr1
Starnd:+
Coordinate:
Start Site(bp):192716333End Site(bp):192716349
External Links:hsa-miR-4426



Disease Information

Disease Name:Benign Ovarian Disease
Disease Category:Urogenital Diseases and Pregnancy Complications
MeSH ID:D010049
Type:Diseases Category/Female Urogenital Diseases and Pregnancy Complications
Alias:Ovarian Diseases//Disease, Ovarian//Diseases, Ovarian//Ovarian Disease



Expression Detail

GEO ID:GSE106817
Description:Integrated extracellular microRNA profiling for ovarian cancer screening
Experimental Design:Cancer vs Control
Case Disease Type:Benign Ovarian Disease
Case Disease SubType:NA
Case Sample:Benign Ovarian Disease
Control Sample:Non-Cancer
Number of Case:29
Number of Control:2759
Number of Samples:2788





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
UFC1
chr1
161152776
161158856
+
NDUFA4
chr7
10931943
10940153
-
N4BP3
chr5
178113532
178126081
+
MTRNR2L11
chr1
237943724
237945275
-
RNF181
chr2
85595725
85597708
+
VMP1
chr17
59707192
59842255
+
DDB1
chr11
61299451
61342596
-
SAP18
chr13
21140514
21149084
+
DOCK6
chr19
11199295
11262524
-
NSMAF
chr8
58583508
58659853
-
APP
chr21
25880550
26171128
-
TMEM170A
chr16
75443054
75465497
-
TKFC
chr11
61333210
61353295
+
CTSZ
chr20
58995185
59007254
-
AL136454.1
chr1
192716132
192716653
+
TPT1
chr13
45333471
45341370
-
PTPN6
chr12
6946468
6961316
+
CAPNS1
chr19
36139953
36150353
+
CCNL2
chr1
1385711
1399335
-
RABGAP1L
chr1
174159410
174995308
+
RACK1
chr5
181236897
181248096
-
HMGN2
chr1
26472440
26476642
+
SEZ6L2
chr16
29871159
29899547
-
GAPDH
chr12
6534512
6538374
+
CD52
chr1
26317958
26320523
+
PCBP2
chr12
53452102
53481162
+
NDUFA11
chr19
5891276
5904006
-
REXO1
chr19
1815248
1848483
-
ZNF655
chr7
99558406
99576453
+
DCAF12
chr9
34086387
34127399
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC023509.1
chr12
53441741
53467528
+
AC105942.1
chr1
94927361
94963616
+
Display:



Experiment Detail

GEO ID:GSE106817
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21263
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2535
Sample treatment protocol:NA
RNA Extract protocol:Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.).
RNA library preparation protocol:miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.



Reference

PMID:30333487
Title:Integrated extracellular microRNA profiling for ovarian cancer screening
Author:Yokoi A, Matsuzaki J, Yamamoto Y, Yoneoka Y, Takahashi K, Shimizu H, Uehara T, Ishikawa M, Ikeda SI, Sonoda T, Kawauchi J, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato K, Kato T, Ochiya T
Journal:Nat Commun. 2018 Oct 17;9(1):4319.
Description:to develop an optimal detection method, we use microarrays to obtain comprehensive miRNA profiles from 4046 serum samples, including 428 patients with ovarian tumors.