exRNAdisease

Entry Detail

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General Information

Database ID: exR0093951 RNA Name: hsa-miR-4485-3p RNA Type: miRNA Chromosome: chr11 Starnd: - Coordinate: Start Site(bp): 10508277 End Site(bp): 10508296 External Links: hsa-miR-4485-3p

Disease Information

Disease Name: Benign Ovarian Disease Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D010049 Type: Diseases Category/Female Urogenital Diseases and Pregnancy Complications Alias: Ovarian Diseases//Disease, Ovarian//Diseases, Ovarian//Ovarian Disease

Expression Detail

GEO ID: GSE106817 Description: Integrated extracellular microRNA profiling for ovarian cancer screening Experimental Design: Cancer vs Control Case Disease Type: Benign Ovarian Disease Case Disease SubType: NA Case Sample: Benign Ovarian Disease Control Sample: Non-Cancer Number of Case: 29 Number of Control: 2759 Number of Samples: 2788

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand C11orf24 chr11 68261338 68272001 - CDK4 chr12 57747727 57756013 - CKAP5 chr11 46743048 46846308 - CYB561A3 chr11 61348745 61362299 - SERINC1 chr6 122443351 122471807 - NES chr1 156668763 156677407 - NDUFB11 chrX 47142216 47145504 - FUBP1 chr1 77944055 77979110 - RPL27 chr17 42998273 43002959 + YEATS2 chr3 183697797 183812624 + CIRBP chr19 1259384 1274880 + DNM1 chr9 128191655 128255248 + MAP3K11 chr11 65597756 65615382 - RPL13 chr16 89560657 89566828 + EXOSC6 chr16 70246778 70251940 - SBF2 chr11 9778667 10294207 - HSPA8 chr11 123057489 123063230 - RPS27A chr2 55231903 55235853 + EIF3F chr11 7970251 8001862 + RNASEH2C chr11 65714005 65720818 - FAU chr11 65120630 65122177 - HSP90AB1 chr6 44246166 44253888 + RPS3 chr11 75399515 75422280 + NR3C1 chr5 143277931 143435512 - SPG11 chr15 44562696 44663678 - MTRNR2L6 chr7 142666272 142667718 + LGR4 chr11 27365961 27472790 - FRMD8 chr11 65386621 65413525 + CRTC3 chr15 90529923 90645345 + MTRNR2L12 chr3 96617188 96618236 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand MALAT1 chr11 65497688 65506516 + XIST chrX 73820649 73852723 - AD000090.1 chr19 35557956 35581954 + LINC01002 chr19 198264 246544 - Display:

Experiment Detail

GEO ID: GSE106817 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2535 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30333487 Title: Integrated extracellular microRNA profiling for ovarian cancer screening Author: Yokoi A, Matsuzaki J, Yamamoto Y, Yoneoka Y, Takahashi K, Shimizu H, Uehara T, Ishikawa M, Ikeda SI, Sonoda T, Kawauchi J, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato K, Kato T, Ochiya T Journal: Nat Commun. 2018 Oct 17;9(1):4319. Description: to develop an optimal detection method, we use microarrays to obtain comprehensive miRNA profiles from 4046 serum samples, including 428 patients with ovarian tumors.