Entry Detail


General Information

Database ID:exR0093959
RNA Name:hsa-miR-4492
RNA Type:miRNA
Chromosome:chr11
Starnd:+
Coordinate:
Start Site(bp):118910765End Site(bp):118910781
External Links:hsa-miR-4492



Disease Information

Disease Name:Benign Ovarian Disease
Disease Category:Urogenital Diseases and Pregnancy Complications
MeSH ID:D010049
Type:Diseases Category/Female Urogenital Diseases and Pregnancy Complications
Alias:Ovarian Diseases//Disease, Ovarian//Diseases, Ovarian//Ovarian Disease



Expression Detail

GEO ID:GSE106817
Description:Integrated extracellular microRNA profiling for ovarian cancer screening
Experimental Design:Cancer vs Control
Case Disease Type:Benign Ovarian Disease
Case Disease SubType:NA
Case Sample:Benign Ovarian Disease
Control Sample:Non-Cancer
Number of Case:29
Number of Control:2759
Number of Samples:2788





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AGFG1
chr2
227472152
227561214
+
NRARP
chr9
137299631
137302271
-
RHOA
chr3
49359145
49412998
-
AATF
chr17
36948954
37056871
+
ANOS1
chrX
8528874
8732137
-
DDRGK1
chr20
3190350
3204685
-
FBXL3
chr13
76992598
77027195
-
LEPR
chr1
65420652
65641559
+
MDP1
chr14
24213943
24216070
-
MELTF
chr3
196988621
197029817
-
NCKAP5L
chr12
49791146
49828750
-
PKN3
chr9
128702503
128720916
+
RNF149
chr2
101271219
101308701
-
SH3BP2
chr4
2793071
2841098
+
SNAPC2
chr19
7920338
7923250
+
SOCS2
chr12
93569814
93583487
+
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AL096870.2
chr14
24209646
24215987
-
Display:



Experiment Detail

GEO ID:GSE106817
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21263
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2535
Sample treatment protocol:NA
RNA Extract protocol:Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.).
RNA library preparation protocol:miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.



Reference

PMID:30333487
Title:Integrated extracellular microRNA profiling for ovarian cancer screening
Author:Yokoi A, Matsuzaki J, Yamamoto Y, Yoneoka Y, Takahashi K, Shimizu H, Uehara T, Ishikawa M, Ikeda SI, Sonoda T, Kawauchi J, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato K, Kato T, Ochiya T
Journal:Nat Commun. 2018 Oct 17;9(1):4319.
Description:to develop an optimal detection method, we use microarrays to obtain comprehensive miRNA profiles from 4046 serum samples, including 428 patients with ovarian tumors.