exRNAdisease

Entry Detail

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General Information

Database ID: exR0093980 RNA Name: hsa-miR-4508 RNA Type: miRNA Chromosome: chr15 Starnd: - Coordinate: Start Site(bp): 23562107 End Site(bp): 23562123 External Links: hsa-miR-4508

Disease Information

Disease Name: Benign Ovarian Disease Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D010049 Type: Diseases Category/Female Urogenital Diseases and Pregnancy Complications Alias: Ovarian Diseases//Disease, Ovarian//Diseases, Ovarian//Ovarian Disease

Expression Detail

GEO ID: GSE106817 Description: Integrated extracellular microRNA profiling for ovarian cancer screening Experimental Design: Cancer vs Control Case Disease Type: Benign Ovarian Disease Case Disease SubType: NA Case Sample: Benign Ovarian Disease Control Sample: Non-Cancer Number of Case: 29 Number of Control: 2759 Number of Samples: 2788

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand USP22 chr17 20999596 21043760 - AC005943.1 chr19 1578339 1605445 - ADNP2 chr18 80109262 80147523 + ANAPC1 chr2 111611639 111884690 - ANKRD54 chr22 37830855 37849327 - CDC42BPB chr14 102932380 103057549 - COA1 chr7 43608456 43729717 - CSNK1G2 chr19 1941172 1981338 + CTC1 chr17 8224815 8248056 - EID2 chr19 39538707 39540161 - ESYT2 chr7 158730995 158830253 - FUS chr16 31180110 31194871 + LTBP3 chr11 65538805 65558930 - MBD3 chr19 1573596 1592865 - NDUFB4 chr3 120596328 120602507 + OXTR chr3 8750408 8769628 - PROB1 chr5 139390592 139395104 - SCAF4 chr21 31671000 31732118 - SLBP chr4 1692731 1712344 - TM9SF1 chr14 24189149 24195687 - TMCO3 chr13 113491021 113554590 + UBE3A chr15 25333728 25439051 - URI1 chr19 29923644 30016612 + UROS chr10 125784980 125823258 - USP28 chr11 113797874 113875570 - WRAP53 chr17 7686071 7703502 + ZNF580 chr19 55635016 55643470 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand HCG18 chr6 30286690 30327382 - Display:

Experiment Detail

GEO ID: GSE106817 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2535 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30333487 Title: Integrated extracellular microRNA profiling for ovarian cancer screening Author: Yokoi A, Matsuzaki J, Yamamoto Y, Yoneoka Y, Takahashi K, Shimizu H, Uehara T, Ishikawa M, Ikeda SI, Sonoda T, Kawauchi J, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato K, Kato T, Ochiya T Journal: Nat Commun. 2018 Oct 17;9(1):4319. Description: to develop an optimal detection method, we use microarrays to obtain comprehensive miRNA profiles from 4046 serum samples, including 428 patients with ovarian tumors.