exRNAdisease

Entry Detail

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General Information

Database ID: exR0094154 RNA Name: hsa-miR-4709-3p RNA Type: miRNA Chromosome: chr14 Starnd: - Coordinate: Start Site(bp): 74480135 End Site(bp): 74480157 External Links: hsa-miR-4709-3p

Disease Information

Disease Name: Benign Ovarian Disease Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D010049 Type: Diseases Category/Female Urogenital Diseases and Pregnancy Complications Alias: Ovarian Diseases//Disease, Ovarian//Diseases, Ovarian//Ovarian Disease

Expression Detail

GEO ID: GSE106817 Description: Integrated extracellular microRNA profiling for ovarian cancer screening Experimental Design: Cancer vs Control Case Disease Type: Benign Ovarian Disease Case Disease SubType: NA Case Sample: Benign Ovarian Disease Control Sample: Non-Cancer Number of Case: 29 Number of Control: 2759 Number of Samples: 2788

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand BCORL1 chrX 129981107 130058083 + COQ8A chr1 226897536 226987545 + DNAJB6 chr7 157335381 157417439 + LAMC1 chr1 183023420 183145592 + PURA chr5 140107777 140125619 + TMEM167A chr5 83052846 83077863 - BIK chr22 43110750 43129712 + CLSTN3 chr12 7129698 7158945 + DHX16 chr6 30653119 30673006 - EMC4 chr15 34225013 34230156 + ETV3 chr1 157121191 157138474 - GATM chr15 45361124 45402327 - MED1 chr17 39404285 39451272 - MED28 chr4 17614641 17634105 + MSH3 chr5 80654652 80876815 + MTRNR2L12 chr3 96617188 96618236 - NDUFA4 chr7 10931943 10940153 - NPC2 chr14 74476192 74494177 - PLBD1 chr12 14503661 14567883 - PLEKHA5 chr12 19129752 19376400 + RACK1 chr5 181236897 181248096 - RBM15B chr3 51391285 51397908 + SLC50A1 chr1 155135344 155138857 + TPRG1L chr1 3625015 3630127 + WNK1 chr12 752579 911452 + miRNA targets: NA circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE106817 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2535 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30333487 Title: Integrated extracellular microRNA profiling for ovarian cancer screening Author: Yokoi A, Matsuzaki J, Yamamoto Y, Yoneoka Y, Takahashi K, Shimizu H, Uehara T, Ishikawa M, Ikeda SI, Sonoda T, Kawauchi J, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato K, Kato T, Ochiya T Journal: Nat Commun. 2018 Oct 17;9(1):4319. Description: to develop an optimal detection method, we use microarrays to obtain comprehensive miRNA profiles from 4046 serum samples, including 428 patients with ovarian tumors.