Entry Detail


General Information

Database ID:exR0094685
RNA Name:hsa-miR-588
RNA Type:miRNA
Chromosome:chr6
Starnd:+
Coordinate:
Start Site(bp):126484646End Site(bp):126484666
External Links:hsa-miR-588



Disease Information

Disease Name:Benign Ovarian Disease
Disease Category:Urogenital Diseases and Pregnancy Complications
MeSH ID:D010049
Type:Diseases Category/Female Urogenital Diseases and Pregnancy Complications
Alias:Ovarian Diseases//Disease, Ovarian//Diseases, Ovarian//Ovarian Disease



Expression Detail

GEO ID:GSE106817
Description:Integrated extracellular microRNA profiling for ovarian cancer screening
Experimental Design:Cancer vs Control
Case Disease Type:Benign Ovarian Disease
Case Disease SubType:NA
Case Sample:Benign Ovarian Disease
Control Sample:Non-Cancer
Number of Case:29
Number of Control:2759
Number of Samples:2788





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ADGRE5
chr19
14380501
14408725
+
ARHGDIA
chr17
81867721
81871378
-
EDEM3
chr1
184690237
184754907
-
EIF1AD
chr11
65996545
66002176
-
FURIN
chr15
90868588
90883458
+
GLIS2
chr16
4314761
4339597
+
NID1
chr1
235975830
236065109
-
NIP7
chr16
69337996
69343106
+
NT5DC3
chr12
103770453
103841234
-
STK40
chr1
36339624
36385896
-
TSPAN14
chr10
80454166
80533124
+
TUB
chr11
8019244
8106112
+
ZBTB39
chr12
56998836
57006546
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001025
chr2
69565029
69565697
-
hsa_circ_0000384
chr12
27867712
27877119
+
hsa_circ_0001247
chr22
46125304
46136418
+
hsa_circ_0000284
chr11
33307958
33309057
+
hsa_circ_0000126
chr1
150997086
150999803
+
hsa_circ_0000744
chr17
15968183
15971435
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC007161.3
chr7
7640752
8004053
+
AL022311.1
chr22
37876148
37895563
+
AL359924.1
chr1
237862175
237928321
+
H19
chr11
1995176
2001470
-
MIR497HG
chr17
7015818
7019659
-
NEAT1
chr11
65422774
65445540
+
PINK1-AS
chr1
20642657
20652193
-
SNHG8
chr4
118278709
118285316
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE106817
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21263
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2535
Sample treatment protocol:NA
RNA Extract protocol:Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.).
RNA library preparation protocol:miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.



Reference

PMID:30333487
Title:Integrated extracellular microRNA profiling for ovarian cancer screening
Author:Yokoi A, Matsuzaki J, Yamamoto Y, Yoneoka Y, Takahashi K, Shimizu H, Uehara T, Ishikawa M, Ikeda SI, Sonoda T, Kawauchi J, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato K, Kato T, Ochiya T
Journal:Nat Commun. 2018 Oct 17;9(1):4319.
Description:to develop an optimal detection method, we use microarrays to obtain comprehensive miRNA profiles from 4046 serum samples, including 428 patients with ovarian tumors.