exRNAdisease

Entry Detail

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General Information

Database ID: exR0094785 RNA Name: hsa-miR-641 RNA Type: miRNA Chromosome: chr19 Starnd: - Coordinate: Start Site(bp): 40282603 End Site(bp): 40282626 External Links: hsa-miR-641

Disease Information

Disease Name: Benign Ovarian Disease Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D010049 Type: Diseases Category/Female Urogenital Diseases and Pregnancy Complications Alias: Ovarian Diseases//Disease, Ovarian//Diseases, Ovarian//Ovarian Disease

Expression Detail

GEO ID: GSE106817 Description: Integrated extracellular microRNA profiling for ovarian cancer screening Experimental Design: Cancer vs Control Case Disease Type: Benign Ovarian Disease Case Disease SubType: NA Case Sample: Benign Ovarian Disease Control Sample: Non-Cancer Number of Case: 29 Number of Control: 2759 Number of Samples: 2788

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AIF1L chr9 131096476 131123152 + AKT2 chr19 40230317 40285536 - C19orf47 chr19 40319536 40348527 - CDKN1A chr6 36676460 36687339 + F11R chr1 160995211 161021343 - FOXN3 chr14 89124871 89619149 - GATAD2B chr1 153789030 153923360 - GCNT2 chr6 10492223 10629368 + GNPTAB chr12 101745499 101830959 - HMGA2 chr12 65824131 65966295 + ICE1 chr5 5420664 5490220 + JPT1 chr17 75135248 75168281 - LSM14A chr19 34172504 34229515 + MED13L chr12 115953872 116277719 - PRSS16 chr6 27247701 27256624 + SETD7 chr4 139495941 139606699 - SOCS3 chr17 78356778 78360077 - SYNJ2BP chr14 70366499 70417090 - SYNJ2BP-COX16 chr14 70326064 70417074 - ZDHHC6 chr10 112424428 112446917 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001085 chr2 191765289 191789319 + hsa_circ_0001168 chr20 47691321 47707559 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC125257.1 chr17 41848518 41851447 - AC239868.1 chr1 149861271 149862504 + AL034397.3 chrX 66015461 66020422 + AL049795.2 chr1 32170733 32176568 + AL355075.4 chr14 20343048 20343685 - DLEU2 chr13 49956670 50125720 - LINC00641 chr14 21200079 21206900 - NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - OIP5-AS1 chr15 41283990 41309737 + SNHG1 chr11 62851984 62855953 - SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE106817 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2535 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30333487 Title: Integrated extracellular microRNA profiling for ovarian cancer screening Author: Yokoi A, Matsuzaki J, Yamamoto Y, Yoneoka Y, Takahashi K, Shimizu H, Uehara T, Ishikawa M, Ikeda SI, Sonoda T, Kawauchi J, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato K, Kato T, Ochiya T Journal: Nat Commun. 2018 Oct 17;9(1):4319. Description: to develop an optimal detection method, we use microarrays to obtain comprehensive miRNA profiles from 4046 serum samples, including 428 patients with ovarian tumors.