exRNAdisease

Entry Detail

---



General Information

Database ID: exR0095277 RNA Name: hsa-miR-744-5p RNA Type: miRNA Chromosome: chr17 Starnd: + Coordinate: Start Site(bp): 12081909 End Site(bp): 12081930 External Links: hsa-miR-744-5p

Disease Information

Disease Name: Benign Ovarian Disease Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D010049 Type: Diseases Category/Female Urogenital Diseases and Pregnancy Complications Alias: Ovarian Diseases//Disease, Ovarian//Diseases, Ovarian//Ovarian Disease

Expression Detail

GEO ID: GSE106817 Description: Integrated extracellular microRNA profiling for ovarian cancer screening Experimental Design: Cancer vs Control Case Disease Type: Benign Ovarian Disease Case Disease SubType: NA Case Sample: Benign Ovarian Disease Control Sample: Non-Cancer Number of Case: 29 Number of Control: 2759 Number of Samples: 2788

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AP5S1 chr20 3820524 3828838 + ARHGDIA chr17 81867721 81871378 - ARL8A chr1 202133404 202144743 - C8orf82 chr8 144525733 144529132 - CLSTN1 chr1 9728926 9823984 - CMIP chr16 81445170 81711762 + DLGAP4 chr20 36306336 36528637 + DNAJC30 chr7 73680918 73683453 - EEF1A2 chr20 63488014 63499185 - FAM219A chr9 34398184 34458570 - FAM83H chr8 143723933 143738234 - MGRN1 chr16 4616493 4690974 + MIDN chr19 1248553 1259140 + NFIX chr19 12995608 13098796 + NRARP chr9 137299631 137302271 - PHB2 chr12 6965327 6970753 - PRKCD chr3 53156009 53192717 + PRR12 chr19 49591182 49626439 + RAI14 chr5 34656328 34832612 + SCN1B chr19 35030470 35040449 + SH3GL1 chr19 4360370 4400547 - SMAD3 chr15 67063763 67195169 + SPRED2 chr2 65310851 65432637 - SYVN1 chr11 65121780 65134533 - WNT5A chr3 55465715 55490539 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC002116.1 chr19 36008638 36014235 - AC008738.7 chr19 33207129 33207639 + AL356488.2 chr1 109100193 109100619 + GAS5 chr1 173858559 173868882 - Display:

Experiment Detail

GEO ID: GSE106817 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2535 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30333487 Title: Integrated extracellular microRNA profiling for ovarian cancer screening Author: Yokoi A, Matsuzaki J, Yamamoto Y, Yoneoka Y, Takahashi K, Shimizu H, Uehara T, Ishikawa M, Ikeda SI, Sonoda T, Kawauchi J, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato K, Kato T, Ochiya T Journal: Nat Commun. 2018 Oct 17;9(1):4319. Description: to develop an optimal detection method, we use microarrays to obtain comprehensive miRNA profiles from 4046 serum samples, including 428 patients with ovarian tumors.