Entry Detail


General Information

Database ID:exR0095292
RNA Name:hsa-miR-769-5p
RNA Type:miRNA
Chromosome:chr19
Starnd:+
Coordinate:
Start Site(bp):46018961End Site(bp):46018982
External Links:hsa-miR-769-5p



Disease Information

Disease Name:Benign Ovarian Disease
Disease Category:Urogenital Diseases and Pregnancy Complications
MeSH ID:D010049
Type:Diseases Category/Female Urogenital Diseases and Pregnancy Complications
Alias:Ovarian Diseases//Disease, Ovarian//Diseases, Ovarian//Ovarian Disease



Expression Detail

GEO ID:GSE106817
Description:Integrated extracellular microRNA profiling for ovarian cancer screening
Experimental Design:Cancer vs Control
Case Disease Type:Benign Ovarian Disease
Case Disease SubType:NA
Case Sample:Benign Ovarian Disease
Control Sample:Non-Cancer
Number of Case:29
Number of Control:2759
Number of Samples:2788





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ACVR1B
chr12
51951699
51997078
+
ANGEL1
chr14
76786168
76826246
-
ASB1
chr2
238426742
238452250
+
BMPR2
chr2
202376327
202567751
+
CAPNS1
chr19
36139953
36150353
+
CBFB
chr16
67028984
67101058
+
CLDN11
chr3
170418865
170454733
+
CLN8
chr8
1755778
1801711
+
DBNDD1
chr16
90004871
90020128
-
DCTN4
chr5
150708440
150759109
-
EIF1AD
chr11
65996545
66002176
-
EIF1AX
chrX
20124525
20141838
-
FOXK1
chr7
4682295
4771442
+
LONRF2
chr2
100271875
100322501
-
MDM4
chr1
204516379
204558120
+
MRTO4
chr1
19251805
19260128
+
NUSAP1
chr15
41320794
41381050
+
PLCD3
chr17
45108959
45133354
-
PRKAA1
chr5
40759379
40798374
-
PXN
chr12
120210439
120265771
-
RHPN1
chr8
143368876
143384221
+
RUNX1
chr21
34787801
36004667
-
TFAP4
chr16
4257186
4273075
-
VAT1
chr17
43014607
43025123
-
YPEL5
chr2
30146941
30160533
+
ZDHHC9
chrX
129803288
129843909
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC245033.4
chr15
82533175
82540008
-
LINC00324
chr17
8220642
8224043
-
MALAT1
chr11
65497688
65506516
+
SNHG1
chr11
62851984
62855953
-
Display:



Experiment Detail

GEO ID:GSE106817
Sample Source:Blood
Source Fraction:Serum
Platform:GPL21263
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2535
Sample treatment protocol:NA
RNA Extract protocol:Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.).
RNA library preparation protocol:miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.



Reference

PMID:30333487
Title:Integrated extracellular microRNA profiling for ovarian cancer screening
Author:Yokoi A, Matsuzaki J, Yamamoto Y, Yoneoka Y, Takahashi K, Shimizu H, Uehara T, Ishikawa M, Ikeda SI, Sonoda T, Kawauchi J, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato K, Kato T, Ochiya T
Journal:Nat Commun. 2018 Oct 17;9(1):4319.
Description:to develop an optimal detection method, we use microarrays to obtain comprehensive miRNA profiles from 4046 serum samples, including 428 patients with ovarian tumors.