exRNAdisease

Entry Detail

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General Information

Database ID: exR0095455 RNA Name: hsa-miR-106a-5p RNA Type: miRNA Chromosome: chrX Starnd: - Coordinate: Start Site(bp): 134170244 End Site(bp): 134170266 External Links: hsa-miR-106a-5p

Disease Information

Disease Name: Borderline Ovarian Tumor Disease Category: Cancers MeSH ID: D010051 Type: Neoplasms/Urogenital Neoplasms Alias: Ovarian Neoplasms//Neoplasm, Ovarian//Ovarian Neoplasm//Ovary Neoplasms//Neoplasm, Ovary//Neoplasms, Ovary//Ovary Neoplasm//Neoplasms, Ovarian//Ovary Cancer//Cancer, Ovary//Cancers, Ovary//Ovary Cancers//Ovarian Cancer//Cancer, Ovarian//Cancers, Ovarian//Ovarian Cancers//Cancer of Ovary//Cancer of the Ovary

Expression Detail

GEO ID: GSE106817 Description: Integrated extracellular microRNA profiling for ovarian cancer screening Experimental Design: Cancer vs Control Case Disease Type: Benign Ovarian Disease Case Disease SubType: NA Case Sample: Borderline Ovarian Tumor Control Sample: Non-Cancer Number of Case: 29 Number of Control: 2759 Number of Samples: 2788

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AP1S1 chr7 101154456 101161596 + LDLRAD3 chr11 35943981 36232136 + PLEKHM1 chr17 45435900 45490749 - MBP chr18 76978827 77133683 - WDR37 chr10 1049538 1132384 + CLOCK chr4 55427903 55546909 - FAM72D chr1 145095974 145112696 + STRN3 chr14 30893799 31026401 - PBXIP1 chr1 154944076 154956123 - MTHFR chr1 11785723 11806455 - ADARB1 chr21 45073853 45226560 + NAA16 chr13 41311267 41377030 + NSD2 chr4 1871393 1982207 + CYLD chr16 50742050 50801935 + LONP2 chr16 48244300 48363122 + ZNF566 chr19 36445119 36489902 - SCAMP2 chr15 74843730 74873365 - BTN3A1 chr6 26402237 26415208 + CCDC6 chr10 59788747 59906556 - C9orf40 chr9 74946583 74952912 - ZDHHC12 chr9 128720870 128724127 - PTP4A1 chr6 63521746 63583436 + CDK6 chr7 92604921 92836594 - FCF1 chr14 74713144 74738620 + ARMC8 chr3 138187248 138298384 + SEC16A chr9 136440096 136483759 - CAPRIN1 chr11 34051731 34102610 + PDRG1 chr20 31944337 31952046 - MSTO1 chr1 155610188 155614971 + WASF3 chr13 26557683 26688948 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001495 chr5 68470703 68471364 + hsa_circ_0000494 chr13 76134888 76143643 + hsa_circ_0000018 chr1 15860731 15863309 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC015871.3 chr15 79920195 79922455 - AC021078.1 chr5 149494314 149504670 - AC021092.1 chr19 44103007 44113183 - AC024940.6 chr12 31280422 31280895 - AC084082.1 chr8 66112667 66126632 + AC087477.2 chr15 96354237 96405235 + AC243964.3 chr19 44631573 44725217 - AL031428.1 chr1 23020147 23088058 - AL137782.1 chr13 75549773 75807120 + AL158206.1 chr9 19453209 19455173 + AL161772.1 chr13 20699307 20703718 - ARHGAP27P1-BPTFP1-KPNA2P3 chr17 64749663 64781707 - CKMT2-AS1 chr5 81201341 81301565 - EPB41L4A-AS1 chr5 112160526 112164818 + ERICD chr8 140636281 140638283 + FGD5-AS1 chr3 14920347 14948424 - H19 chr11 1995176 2001470 - HAGLR chr2 176164051 176188958 - HOTAIR chr12 53962308 53974956 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE106817 Sample Source: Blood Source Fraction: Serum Platform: GPL21263 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2535 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted each from 300uL serum samples using 3D-Gene® RNA extraction reagent from liquid sample kit (Toray Industries, Inc.). RNA library preparation protocol: miRNA was labeled using 3D-Gene® miRNA Labeling kit in accordance with the manufacturer's instructions.

Reference

PMID: 30333487 Title: Integrated extracellular microRNA profiling for ovarian cancer screening Author: Yokoi A, Matsuzaki J, Yamamoto Y, Yoneoka Y, Takahashi K, Shimizu H, Uehara T, Ishikawa M, Ikeda SI, Sonoda T, Kawauchi J, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato K, Kato T, Ochiya T Journal: Nat Commun. 2018 Oct 17;9(1):4319. Description: to develop an optimal detection method, we use microarrays to obtain comprehensive miRNA profiles from 4046 serum samples, including 428 patients with ovarian tumors.