exRNAdisease

Entry Detail

---



General Information

Database ID: exR0153122 RNA Name: hsa-miR-122-5p RNA Type: miRNA Chromosome: chr18 Starnd: + Coordinate: Start Site(bp): 58451088 End Site(bp): 58451109 External Links: hsa-miR-122-5p

Disease Information

Disease Name: Prostate Cancer Disease Category: Cancers MeSH ID: D011471 Type: Neoplasms/Digestive System Neoplasms Alias: Prostatic Neoplasms//Prostate Neoplasms//Neoplasms, Prostate//Neoplasm, Prostate//Prostate Neoplasm//Neoplasms, Prostatic//Neoplasm, Prostatic//Prostatic Neoplasm//Prostate Cancer//Cancer, Prostate//Cancers, Prostate//Prostate Cancers//Cancer of the Prostate//Prostatic Cancer//Cancer, Prostatic//Cancers, Prostatic//Prostatic Cancers//Cancer of Prostate

Expression Detail

GEO ID: GSE113234 Description: Circulating microRNAs combined with PSA for an accurate and non-invasive prostate cancer detection Experimental Design: Cancer vs Control Case Disease Type: Prostate Cancer Case Disease SubType: NA Case Sample: Prostate Cancer Control Sample: Healthy Number of Case: 60 Number of Control: 27 Number of Samples: 87

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand MSI2 chr17 57255851 57684689 + FAM102A chr9 127940582 127980989 - NAGK chr2 71064344 71079808 + SPRED2 chr2 65310851 65432637 - HGSNAT chr8 43140464 43202855 + PPDPF chr20 63520765 63522206 + SH3GL1 chr19 4360370 4400547 - SETD1A chr16 30957754 30984664 + PEA15 chr1 160205337 160215376 + C19orf54 chr19 40740856 40751553 - PIP4K2A chr10 22534854 22714578 - RPRD1B chr20 38033725 38127780 + CACNG4 chr17 66964707 67033398 + SOX11 chr2 5692384 5701385 + IGFBP5 chr2 216672105 216695549 - RAB1B chr11 66268590 66277492 + CSRP1 chr1 201483530 201509456 - VTI1A chr10 112446998 112818744 + ZNF3 chr7 100064033 100082548 - NHLRC3 chr13 39038306 39050109 + ZNF614 chr19 52012765 52030240 - NDOR1 chr9 137205685 137217009 + ALDOA chr16 30064164 30070457 + GRK3 chr22 25564675 25729294 + C19orf47 chr19 40319536 40348527 - SLC9A1 chr1 27098809 27166981 - STK4 chr20 44966479 45080021 + IER2 chr19 13150411 13154911 + PRR12 chr19 49591182 49626439 + KRT7 chr12 52232520 52252186 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC021092.1 chr19 44103007 44113183 - AC103702.1 chr17 48579630 48582259 - AL358472.3 chr1 153966516 153966930 + AL645465.1 chr1 244375100 244409592 - DSCAM-AS1 chr21 40383083 40385358 + NEAT1 chr11 65422774 65445540 + SNHG7 chr9 136721366 136728184 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE113234 Sample Source: Blood Source Fraction: Plasma Platform: GPL19730 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1972 Sample treatment protocol: NA RNA Extract protocol: Extraction was performed using miRNEasy serum/plasma kit from Qiagen. RNA library preparation protocol: Briefly, 4 ul of totRNA were dephosphorylated and denaturated; then a ligation and labeling step with Cy3 was performed

Reference

PMID: 30452625 Title: Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection Author: Mello-Grand M, Gregnanin I, Sacchetto L, Ostano P, Zitella A, Bottoni G, Oderda M, Marra G, Munegato S, Pardini B, Naccarati A, Gasparini M, Gontero P, Chiorino G Journal: Carcinogenesis. 2019 Apr 29;40(2):246-253. Description: we propose to combine circulating microRNAs (miRs) with PSA, to improve the diagnostic route for PCa