Entry Detail


General Information

Database ID:exR0153156
RNA Name:hsa-miR-1248
RNA Type:miRNA
Chromosome:chr3
Starnd:+
Coordinate:
Start Site(bp):186786675End Site(bp):186786701
External Links:hsa-miR-1248



Disease Information

Disease Name:Prostate Cancer
Disease Category:Cancers
MeSH ID:D011471
Type:Neoplasms/Digestive System Neoplasms
Alias:Prostatic Neoplasms//Prostate Neoplasms//Neoplasms, Prostate//Neoplasm, Prostate//Prostate Neoplasm//Neoplasms, Prostatic//Neoplasm, Prostatic//Prostatic Neoplasm//Prostate Cancer//Cancer, Prostate//Cancers, Prostate//Prostate Cancers//Cancer of the Prostate//Prostatic Cancer//Cancer, Prostatic//Cancers, Prostatic//Prostatic Cancers//Cancer of Prostate



Expression Detail

GEO ID:GSE113234
Description:Circulating microRNAs combined with PSA for an accurate and non-invasive prostate cancer detection
Experimental Design:Cancer vs Control
Case Disease Type:Prostate Cancer
Case Disease SubType:NA
Case Sample:Prostate Cancer
Control Sample:Healthy
Number of Case:60
Number of Control:27
Number of Samples:87





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
CHD9
chr16
53055033
53329150
+
ADAM10
chr15
58588809
58749791
-
COA1
chr7
43608456
43729717
-
COMT
chr22
19941733
19969975
+
COPB1
chr11
14443440
14500027
-
EIF3L
chr22
37848868
37889407
+
EIF4A2
chr3
186783205
186789897
+
GSPT1
chr16
11868128
11916082
-
HNRNPA0
chr5
137745651
137754363
-
INO80B
chr2
74455087
74457944
+
INO80B-WBP1
chr2
74455088
74460884
+
KCTD10
chr12
109448655
109477359
-
MRPL13
chr8
120380761
120445402
-
RPS25
chr11
119015712
119018691
-
SEC24B
chr4
109433772
109540896
+
SERINC5
chr5
80111651
80256048
-
TM9SF2
chr13
99446311
99564048
+
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
SNHG1
chr11
62851984
62855953
-
Display:



Experiment Detail

GEO ID:GSE113234
Sample Source:Blood
Source Fraction:Plasma
Platform:GPL19730
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:1972
Sample treatment protocol:NA
RNA Extract protocol:Extraction was performed using miRNEasy serum/plasma kit from Qiagen.
RNA library preparation protocol:Briefly, 4 ul of totRNA were dephosphorylated and denaturated; then a ligation and labeling step with Cy3 was performed



Reference

PMID:30452625
Title:Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection
Author:Mello-Grand M, Gregnanin I, Sacchetto L, Ostano P, Zitella A, Bottoni G, Oderda M, Marra G, Munegato S, Pardini B, Naccarati A, Gasparini M, Gontero P, Chiorino G
Journal:Carcinogenesis. 2019 Apr 29;40(2):246-253.
Description:we propose to combine circulating microRNAs (miRs) with PSA, to improve the diagnostic route for PCa