exRNAdisease

Entry Detail

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General Information

Database ID: exR0153213 RNA Name: hsa-miR-129-5p RNA Type: miRNA Chromosome: chr7 Starnd: + Coordinate: Start Site(bp): 128207876 End Site(bp): 128207896 External Links: hsa-miR-129-5p

Disease Information

Disease Name: Prostate Cancer Disease Category: Cancers MeSH ID: D011471 Type: Neoplasms/Digestive System Neoplasms Alias: Prostatic Neoplasms//Prostate Neoplasms//Neoplasms, Prostate//Neoplasm, Prostate//Prostate Neoplasm//Neoplasms, Prostatic//Neoplasm, Prostatic//Prostatic Neoplasm//Prostate Cancer//Cancer, Prostate//Cancers, Prostate//Prostate Cancers//Cancer of the Prostate//Prostatic Cancer//Cancer, Prostatic//Cancers, Prostatic//Prostatic Cancers//Cancer of Prostate

Expression Detail

GEO ID: GSE113234 Description: Circulating microRNAs combined with PSA for an accurate and non-invasive prostate cancer detection Experimental Design: Cancer vs Control Case Disease Type: Prostate Cancer Case Disease SubType: NA Case Sample: Prostate Cancer Control Sample: Healthy Number of Case: 60 Number of Control: 27 Number of Samples: 87

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TNRC6B chr22 40044817 40335808 + KRIT1 chr7 92198969 92246166 - SLC7A2 chr8 17497088 17570573 + TRIM71 chr3 32817997 32897824 + SHCBP1 chr16 46578591 46621379 - NEDD4 chr15 55826922 55993746 - ZNF605 chr12 132918306 132956306 - DDX18 chr2 117814691 117832377 + CPSF7 chr11 61402641 61430031 - RAD1 chr5 34905260 34918989 - UBN2 chr7 139230356 139308236 + DEGS1 chr1 224175756 224193441 + SEC62 chr3 169966635 169998373 + CRK chr17 1420689 1463162 - SLC35E1 chr19 16549831 16572415 - TRIM14 chr9 98069275 98119222 - ALDH5A1 chr6 24494867 24537207 + UFL1 chr6 96521595 96555276 + DUSP14 chr17 37489891 37513501 + WSB1 chr17 27294076 27315926 + DNAJC24 chr11 31369840 31432835 + CHURC1 chr14 64914361 64944591 + MLEC chr12 120687149 120701859 + CAMTA1 chr1 6785454 7769706 + THUMPD1 chr16 20702816 20742084 - EIF4A1 chr17 7572706 7579006 + ACER3 chr11 76860867 77026797 + TTPAL chr20 44475874 44494603 + PDS5A chr4 39822863 39977956 - FBXW7 chr4 152320544 152536092 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000943 chr19 47421744 47440665 + hsa_circ_0001168 chr20 47691321 47707559 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004069.1 chr4 105137280 105140619 - AC097634.1 chr3 71584943 71587409 + AL049795.2 chr1 32170733 32176568 + FGD5-AS1 chr3 14920347 14948424 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + NUTM2A-AS1 chr10 87201647 87342612 - OIP5-AS1 chr15 41283990 41309737 + TBC1D3P1-DHX40P1 chr17 59962363 60018975 - TUG1 chr22 30969245 30979395 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE113234 Sample Source: Blood Source Fraction: Plasma Platform: GPL19730 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1972 Sample treatment protocol: NA RNA Extract protocol: Extraction was performed using miRNEasy serum/plasma kit from Qiagen. RNA library preparation protocol: Briefly, 4 ul of totRNA were dephosphorylated and denaturated; then a ligation and labeling step with Cy3 was performed

Reference

PMID: 30452625 Title: Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection Author: Mello-Grand M, Gregnanin I, Sacchetto L, Ostano P, Zitella A, Bottoni G, Oderda M, Marra G, Munegato S, Pardini B, Naccarati A, Gasparini M, Gontero P, Chiorino G Journal: Carcinogenesis. 2019 Apr 29;40(2):246-253. Description: we propose to combine circulating microRNAs (miRs) with PSA, to improve the diagnostic route for PCa