exRNAdisease

Entry Detail

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General Information

Database ID: exR0153239 RNA Name: hsa-miR-130b-3p RNA Type: miRNA Chromosome: chr22 Starnd: + Coordinate: Start Site(bp): 21653354 End Site(bp): 21653375 External Links: hsa-miR-130b-3p

Disease Information

Disease Name: Prostate Cancer Disease Category: Cancers MeSH ID: D011471 Type: Neoplasms/Digestive System Neoplasms Alias: Prostatic Neoplasms//Prostate Neoplasms//Neoplasms, Prostate//Neoplasm, Prostate//Prostate Neoplasm//Neoplasms, Prostatic//Neoplasm, Prostatic//Prostatic Neoplasm//Prostate Cancer//Cancer, Prostate//Cancers, Prostate//Prostate Cancers//Cancer of the Prostate//Prostatic Cancer//Cancer, Prostatic//Cancers, Prostatic//Prostatic Cancers//Cancer of Prostate

Expression Detail

GEO ID: GSE113234 Description: Circulating microRNAs combined with PSA for an accurate and non-invasive prostate cancer detection Experimental Design: Cancer vs Control Case Disease Type: Prostate Cancer Case Disease SubType: NA Case Sample: Prostate Cancer Control Sample: Healthy Number of Case: 60 Number of Control: 27 Number of Samples: 87

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand MLLT1 chr19 6210381 6279975 - XXYLT1 chr3 195068284 195271159 - STK38L chr12 27243968 27325959 + ZDHHC7 chr16 84974181 85011535 - OSBP chr11 59574398 59615774 - NPAS2 chr2 100820139 100996829 + G6PD chrX 154531391 154547572 - ANKRD52 chr12 56237807 56258384 - ADAR chr1 154582057 154628013 - ZC4H2 chrX 64915802 65034713 - SNX27 chr1 151612006 151699091 + USP47 chr11 11841423 11961887 + ZNF317 chr19 9140397 9163424 + GADD45A chr1 67685201 67688334 + ZBTB7B chr1 155002630 155018522 + CALU chr7 128739292 128773400 + PCYOX1 chr2 70257386 70281185 + MPPED2 chr11 30384493 30586872 - PDRG1 chr20 31944337 31952046 - CD151 chr11 832887 839831 + MGRN1 chr16 4616493 4690974 + TBC1D5 chr3 17157162 18444817 - ELOC chr8 73939169 73972287 - MSTO1 chr1 155610188 155614971 + IKZF4 chr12 56007659 56038435 + APOL6 chr22 35648446 35668404 + TRIM2 chr4 153152342 153339317 + SYNJ1 chr21 32628759 32728048 - RHOA chr3 49359145 49412998 - TGIF2 chr20 36573488 36593950 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000591 chr15 41961025 41962156 + hsa_circ_0001454 chr4 154524454 154533552 + hsa_circ_0000384 chr12 27867712 27877119 + hsa_circ_0001723 chr7 91924202 91948826 + hsa_circ_0000892 chr19 11941431 12014514 + hsa_circ_0001605 chr6 42903447 42905047 + hsa_circ_0000155 chr1 168007608 168014465 + hsa_circ_0001495 chr5 68470703 68471364 + hsa_circ_0000943 chr19 47421744 47440665 + hsa_circ_0000018 chr1 15860731 15863309 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC011503.2 chr19 23927788 23929287 + AC021092.1 chr19 44103007 44113183 - AC135050.6 chr16 31122235 31124064 + AC234582.1 chr1 155195004 155205495 + AL031595.3 chr22 44139365 44153626 + AL049840.4 chr14 103694516 103695050 - AL158206.1 chr9 19453209 19455173 + AL158825.2 chr9 75009828 75016036 - AL603839.3 chr1 40493157 40508661 - CKMT2-AS1 chr5 81201341 81301565 - H19 chr11 1995176 2001470 - HAGLR chr2 176164051 176188958 - KCNQ1OT1 chr11 2608328 2699994 - LINC01089 chr12 121795267 121803906 - MIR17HG chr13 91347820 91354579 + NEAT1 chr11 65422774 65445540 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE113234 Sample Source: Blood Source Fraction: Plasma Platform: GPL19730 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1972 Sample treatment protocol: NA RNA Extract protocol: Extraction was performed using miRNEasy serum/plasma kit from Qiagen. RNA library preparation protocol: Briefly, 4 ul of totRNA were dephosphorylated and denaturated; then a ligation and labeling step with Cy3 was performed

Reference

PMID: 30452625 Title: Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection Author: Mello-Grand M, Gregnanin I, Sacchetto L, Ostano P, Zitella A, Bottoni G, Oderda M, Marra G, Munegato S, Pardini B, Naccarati A, Gasparini M, Gontero P, Chiorino G Journal: Carcinogenesis. 2019 Apr 29;40(2):246-253. Description: we propose to combine circulating microRNAs (miRs) with PSA, to improve the diagnostic route for PCa