exRNAdisease

Entry Detail

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General Information

Database ID: exR0153293 RNA Name: hsa-miR-151a-3p RNA Type: miRNA Chromosome: chr8 Starnd: - Coordinate: Start Site(bp): 140732587 End Site(bp): 140732607 External Links: hsa-miR-151a-3p

Disease Information

Disease Name: Prostate Cancer Disease Category: Cancers MeSH ID: D011471 Type: Neoplasms/Digestive System Neoplasms Alias: Prostatic Neoplasms//Prostate Neoplasms//Neoplasms, Prostate//Neoplasm, Prostate//Prostate Neoplasm//Neoplasms, Prostatic//Neoplasm, Prostatic//Prostatic Neoplasm//Prostate Cancer//Cancer, Prostate//Cancers, Prostate//Prostate Cancers//Cancer of the Prostate//Prostatic Cancer//Cancer, Prostatic//Cancers, Prostatic//Prostatic Cancers//Cancer of Prostate

Expression Detail

GEO ID: GSE113234 Description: Circulating microRNAs combined with PSA for an accurate and non-invasive prostate cancer detection Experimental Design: Cancer vs Control Case Disease Type: Prostate Cancer Case Disease SubType: NA Case Sample: Prostate Cancer Control Sample: Healthy Number of Case: 60 Number of Control: 27 Number of Samples: 87

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACP1 chr2 264140 278283 + PCDHA1 chr5 140786136 141012347 + PCDHA10 chr5 140855883 141012347 + PCDHA11 chr5 140868183 141012344 + PCDHA12 chr5 140875302 141012347 + PCDHA13 chr5 140882124 141012347 + PCDHA2 chr5 140794852 141012347 + PCDHA3 chr5 140801028 141012347 + PCDHA4 chr5 140806929 141012347 + PCDHA5 chr5 140821604 141012347 + PCDHA6 chr5 140827958 141012347 + PCDHA7 chr5 140834248 141012347 + PCDHA8 chr5 140841187 141012347 + PCDHA9 chr5 140847463 141012344 + PCDHAC1 chr5 140926369 141012344 + PCDHAC2 chr5 140966470 141012347 + STRBP chr9 123109500 123268586 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC044784.1 chr10 8970125 8973468 + AC104794.2 chr2 10083781 10086101 + AL160006.1 chr1 110058340 110062555 + SCARNA9 chr11 93721513 93721865 + TUG1 chr22 30969245 30979395 + Display:

Experiment Detail

GEO ID: GSE113234 Sample Source: Blood Source Fraction: Plasma Platform: GPL19730 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1972 Sample treatment protocol: NA RNA Extract protocol: Extraction was performed using miRNEasy serum/plasma kit from Qiagen. RNA library preparation protocol: Briefly, 4 ul of totRNA were dephosphorylated and denaturated; then a ligation and labeling step with Cy3 was performed

Reference

PMID: 30452625 Title: Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection Author: Mello-Grand M, Gregnanin I, Sacchetto L, Ostano P, Zitella A, Bottoni G, Oderda M, Marra G, Munegato S, Pardini B, Naccarati A, Gasparini M, Gontero P, Chiorino G Journal: Carcinogenesis. 2019 Apr 29;40(2):246-253. Description: we propose to combine circulating microRNAs (miRs) with PSA, to improve the diagnostic route for PCa