exRNAdisease

Entry Detail

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General Information

Database ID: exR0153658 RNA Name: hsa-miR-320c RNA Type: miRNA Chromosome: chr18 Starnd: + Coordinate: Start Site(bp): 24321716 End Site(bp): 24321735 External Links: hsa-miR-320c

Disease Information

Disease Name: Prostate Cancer Disease Category: Cancers MeSH ID: D011471 Type: Neoplasms/Digestive System Neoplasms Alias: Prostatic Neoplasms//Prostate Neoplasms//Neoplasms, Prostate//Neoplasm, Prostate//Prostate Neoplasm//Neoplasms, Prostatic//Neoplasm, Prostatic//Prostatic Neoplasm//Prostate Cancer//Cancer, Prostate//Cancers, Prostate//Prostate Cancers//Cancer of the Prostate//Prostatic Cancer//Cancer, Prostatic//Cancers, Prostatic//Prostatic Cancers//Cancer of Prostate

Expression Detail

GEO ID: GSE113234 Description: Circulating microRNAs combined with PSA for an accurate and non-invasive prostate cancer detection Experimental Design: Cancer vs Control Case Disease Type: Prostate Cancer Case Disease SubType: NA Case Sample: Prostate Cancer Control Sample: Healthy Number of Case: 60 Number of Control: 27 Number of Samples: 87

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACAP2 chr3 195274745 195443044 - ASB1 chr2 238426742 238452250 + BLCAP chr20 37492472 37527931 - CGN chr1 151510510 151538692 + CKAP5 chr11 46743048 46846308 - FJX1 chr11 35618460 35620865 + GMCL1 chr2 69829660 69881384 + GNAI2 chr3 50226292 50259362 + HAS3 chr16 69105653 69118719 + MIER3 chr5 56919602 56971675 - PFN1 chr17 4945652 4949061 - SIN3A chr15 75369379 75455842 - SRSF7 chr2 38743599 38751494 - TRIM14 chr9 98069275 98119222 - ZCCHC2 chr18 62523025 62587709 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000417 chr12 69644908 69656342 + hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0000095 chr1 95609446 95616975 + hsa_circ_0000744 chr17 15968183 15971435 - hsa_circ_0000652 chr15 90984737 90986710 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC002044.1 chr16 73014319 73014476 - AC016876.2 chr17 7581964 7584086 - AC092718.4 chr16 81030770 81031485 + AL022311.1 chr22 37876148 37895563 + AL162258.1 chr1 153626332 153634340 - DLEU1 chr13 50082169 50906856 + GAS5 chr1 173858559 173868882 - LINC00641 chr14 21200079 21206900 - MALAT1 chr11 65497688 65506516 + MIR3142HG chr5 160438594 160487426 + NEAT1 chr11 65422774 65445540 + NR2F2-AS1 chr15 96110040 96327361 - OIP5-AS1 chr15 41283990 41309737 + SNHG1 chr11 62851984 62855953 - SNHG12 chr1 28578538 28583132 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE113234 Sample Source: Blood Source Fraction: Plasma Platform: GPL19730 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1972 Sample treatment protocol: NA RNA Extract protocol: Extraction was performed using miRNEasy serum/plasma kit from Qiagen. RNA library preparation protocol: Briefly, 4 ul of totRNA were dephosphorylated and denaturated; then a ligation and labeling step with Cy3 was performed

Reference

PMID: 30452625 Title: Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection Author: Mello-Grand M, Gregnanin I, Sacchetto L, Ostano P, Zitella A, Bottoni G, Oderda M, Marra G, Munegato S, Pardini B, Naccarati A, Gasparini M, Gontero P, Chiorino G Journal: Carcinogenesis. 2019 Apr 29;40(2):246-253. Description: we propose to combine circulating microRNAs (miRs) with PSA, to improve the diagnostic route for PCa