Entry Detail


General Information

Database ID:exR0153902
RNA Name:hsa-miR-422a
RNA Type:miRNA
Chromosome:chr15
Starnd:-
Coordinate:
Start Site(bp):63870989End Site(bp):63871010
External Links:hsa-miR-422a



Disease Information

Disease Name:Prostate Cancer
Disease Category:Cancers
MeSH ID:D011471
Type:Neoplasms/Digestive System Neoplasms
Alias:Prostatic Neoplasms//Prostate Neoplasms//Neoplasms, Prostate//Neoplasm, Prostate//Prostate Neoplasm//Neoplasms, Prostatic//Neoplasm, Prostatic//Prostatic Neoplasm//Prostate Cancer//Cancer, Prostate//Cancers, Prostate//Prostate Cancers//Cancer of the Prostate//Prostatic Cancer//Cancer, Prostatic//Cancers, Prostatic//Prostatic Cancers//Cancer of Prostate



Expression Detail

GEO ID:GSE113234
Description:Circulating microRNAs combined with PSA for an accurate and non-invasive prostate cancer detection
Experimental Design:Cancer vs Control
Case Disease Type:Prostate Cancer
Case Disease SubType:NA
Case Sample:Prostate Cancer
Control Sample:Healthy
Number of Case:60
Number of Control:27
Number of Samples:87





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ARHGAP11A
chr15
32615144
32639941
+
CPEB3
chr10
92046692
92291078
-
FOSL1
chr11
65892049
65900573
-
ISCA1
chr9
86264546
86283102
-
KDM5A
chr12
280057
389320
-
MAP3K14
chr17
45263119
45317029
-
ORAI1
chr12
121626550
121642677
+
PIK3R3
chr1
46040140
46133036
-
PLEKHO2
chr15
64841883
64868002
+
SEH1L
chr18
12947133
12987536
+
SOX4
chr6
21593751
21598619
+
TMEM245
chr9
109015135
109119947
-
TOB2
chr22
41433494
41446801
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001459
chr4
178274461
178274882
+
hsa_circ_0001460
chr4
178274461
178281831
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC023509.1
chr12
53441741
53467528
+
AL049795.2
chr1
32170733
32176568
+
KCNQ1OT1
chr11
2608328
2699994
-
LINC00641
chr14
21200079
21206900
-
MALAT1
chr11
65497688
65506516
+
NORAD
chr20
36045618
36051018
-
OIP5-AS1
chr15
41283990
41309737
+
Display:



Experiment Detail

GEO ID:GSE113234
Sample Source:Blood
Source Fraction:Plasma
Platform:GPL19730
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:1972
Sample treatment protocol:NA
RNA Extract protocol:Extraction was performed using miRNEasy serum/plasma kit from Qiagen.
RNA library preparation protocol:Briefly, 4 ul of totRNA were dephosphorylated and denaturated; then a ligation and labeling step with Cy3 was performed



Reference

PMID:30452625
Title:Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection
Author:Mello-Grand M, Gregnanin I, Sacchetto L, Ostano P, Zitella A, Bottoni G, Oderda M, Marra G, Munegato S, Pardini B, Naccarati A, Gasparini M, Gontero P, Chiorino G
Journal:Carcinogenesis. 2019 Apr 29;40(2):246-253.
Description:we propose to combine circulating microRNAs (miRs) with PSA, to improve the diagnostic route for PCa