Entry Detail


General Information

Database ID:exR0154509
RNA Name:hsa-miR-5094
RNA Type:miRNA
Chromosome:chr15
Starnd:-
Coordinate:
Start Site(bp):89850690End Site(bp):89850711
External Links:hsa-miR-5094



Disease Information

Disease Name:Prostate Cancer
Disease Category:Cancers
MeSH ID:D011471
Type:Neoplasms/Digestive System Neoplasms
Alias:Prostatic Neoplasms//Prostate Neoplasms//Neoplasms, Prostate//Neoplasm, Prostate//Prostate Neoplasm//Neoplasms, Prostatic//Neoplasm, Prostatic//Prostatic Neoplasm//Prostate Cancer//Cancer, Prostate//Cancers, Prostate//Prostate Cancers//Cancer of the Prostate//Prostatic Cancer//Cancer, Prostatic//Cancers, Prostatic//Prostatic Cancers//Cancer of Prostate



Expression Detail

GEO ID:GSE113234
Description:Circulating microRNAs combined with PSA for an accurate and non-invasive prostate cancer detection
Experimental Design:Cancer vs Control
Case Disease Type:Prostate Cancer
Case Disease SubType:NA
Case Sample:Prostate Cancer
Control Sample:Healthy
Number of Case:60
Number of Control:27
Number of Samples:87





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ZNHIT3
chr17
36486629
36499310
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001454
chr4
154524454
154533552
+
hsa_circ_0001005
chr2
53921020
53978078
-
hsa_circ_0000384
chr12
27867712
27877119
+
hsa_circ_0001159
chr20
40161688
40179999
-
hsa_circ_0000698
chr16
47531309
47549512
+
hsa_circ_0001445
chr4
144464661
144465125
+
hsa_circ_0000943
chr19
47421744
47440665
+
hsa_circ_0001667
chr7
810107
814799
+
hsa_circ_0001376
chr3
194169185
194175121
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC074117.1
chr2
27356246
27367622
+
AL356488.2
chr1
109100193
109100619
+
AL359091.1
chr9
128392007
128393510
-
DSCAM-AS1
chr21
40383083
40385358
+
FTX
chrX
73940435
74293574
-
GAS5
chr1
173858559
173868882
-
NEAT1
chr11
65422774
65445540
+
NUTM2B-AS1
chr10
79661394
79826594
-
PDCD4-AS1
chr10
110869868
110872233
-
SNHG3
chr1
28505980
28510892
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE113234
Sample Source:Blood
Source Fraction:Plasma
Platform:GPL19730
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:1972
Sample treatment protocol:NA
RNA Extract protocol:Extraction was performed using miRNEasy serum/plasma kit from Qiagen.
RNA library preparation protocol:Briefly, 4 ul of totRNA were dephosphorylated and denaturated; then a ligation and labeling step with Cy3 was performed



Reference

PMID:30452625
Title:Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection
Author:Mello-Grand M, Gregnanin I, Sacchetto L, Ostano P, Zitella A, Bottoni G, Oderda M, Marra G, Munegato S, Pardini B, Naccarati A, Gasparini M, Gontero P, Chiorino G
Journal:Carcinogenesis. 2019 Apr 29;40(2):246-253.
Description:we propose to combine circulating microRNAs (miRs) with PSA, to improve the diagnostic route for PCa