exRNAdisease

Entry Detail

---



General Information

Database ID: exR0154843 RNA Name: hsa-miR-625-5p RNA Type: miRNA Chromosome: chr14 Starnd: + Coordinate: Start Site(bp): 65471116 End Site(bp): 65471136 External Links: hsa-miR-625-5p

Disease Information

Disease Name: Prostate Cancer Disease Category: Cancers MeSH ID: D011471 Type: Neoplasms/Digestive System Neoplasms Alias: Prostatic Neoplasms//Prostate Neoplasms//Neoplasms, Prostate//Neoplasm, Prostate//Prostate Neoplasm//Neoplasms, Prostatic//Neoplasm, Prostatic//Prostatic Neoplasm//Prostate Cancer//Cancer, Prostate//Cancers, Prostate//Prostate Cancers//Cancer of the Prostate//Prostatic Cancer//Cancer, Prostatic//Cancers, Prostatic//Prostatic Cancers//Cancer of Prostate

Expression Detail

GEO ID: GSE113234 Description: Circulating microRNAs combined with PSA for an accurate and non-invasive prostate cancer detection Experimental Design: Cancer vs Control Case Disease Type: Prostate Cancer Case Disease SubType: NA Case Sample: Prostate Cancer Control Sample: Healthy Number of Case: 60 Number of Control: 27 Number of Samples: 87

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand PPP2R1A chr19 52190048 52229518 + SF3B3 chr16 70523791 70577670 + LRFN1 chr19 39306568 39315336 - SLC6A6 chr3 14402576 14489349 + VPS37B chr12 122865330 122896127 - SMARCC2 chr12 56162359 56189567 - WIZ chr19 15419978 15449956 - SLC7A5 chr16 87830023 87869507 - MED22 chr9 133338312 133348131 - PPARD chr6 35342558 35428191 + FAM102A chr9 127940582 127980989 - ABL2 chr1 179099330 179229684 - PPP6C chr9 125146573 125189939 - ABCF2 chr7 151207837 151227166 - ABHD14A-ACY1 chr3 51974706 51989183 + BCL9L chr11 118893875 118925608 - JUN chr1 58780791 58784047 - NUMB chr14 73275107 73458617 - SDF2 chr17 28648346 28662189 - SREBF2 chr22 41833079 41907307 + COL6A2 chr21 46098112 46132848 + ACY1 chr3 51983340 51989197 + E2F1 chr20 33675477 33686385 - PRDX2 chr19 12796820 12801800 - MSI1 chr12 120341330 120369164 - COPS7B chr2 231781671 231809254 + CPSF7 chr11 61402641 61430031 - SCAMP4 chr19 1905372 1926013 + ITGA5 chr12 54395261 54419266 - RNF44 chr5 176526712 176538025 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001434 chr4 106345352 106377902 - hsa_circ_0001409 chr4 48835417 48859382 + hsa_circ_0001358 chr3 169694733 169706147 + hsa_circ_0001146 chr20 34241449 34246936 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC010542.4 chr16 66549280 66551189 + AC145207.5 chr17 81878425 81881106 - AC234582.1 chr1 155195004 155205495 + H19 chr11 1995176 2001470 - LINC00240 chr6 26956932 27059749 + MALAT1 chr11 65497688 65506516 + SNHG7 chr9 136721366 136728184 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE113234 Sample Source: Blood Source Fraction: Plasma Platform: GPL19730 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1972 Sample treatment protocol: NA RNA Extract protocol: Extraction was performed using miRNEasy serum/plasma kit from Qiagen. RNA library preparation protocol: Briefly, 4 ul of totRNA were dephosphorylated and denaturated; then a ligation and labeling step with Cy3 was performed

Reference

PMID: 30452625 Title: Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection Author: Mello-Grand M, Gregnanin I, Sacchetto L, Ostano P, Zitella A, Bottoni G, Oderda M, Marra G, Munegato S, Pardini B, Naccarati A, Gasparini M, Gontero P, Chiorino G Journal: Carcinogenesis. 2019 Apr 29;40(2):246-253. Description: we propose to combine circulating microRNAs (miRs) with PSA, to improve the diagnostic route for PCa