exRNAdisease

Entry Detail

General Information

Database ID:

exR0154859

RNA Name:

hsa-miR-639

RNA Type:

miRNA

Chromosome:

chr19

Starnd:

+

Coordinate:

Start Site(bp):

14529603

End Site(bp):

14529625

External Links:

Disease Information

Disease Name:	Prostate Cancer
Disease Category:	Cancers
MeSH ID:	D011471
Type:	Neoplasms/Digestive System Neoplasms
Alias:	Prostatic Neoplasms//Prostate Neoplasms//Neoplasms, Prostate//Neoplasm, Prostate//Prostate Neoplasm//Neoplasms, Prostatic//Neoplasm, Prostatic//Prostatic Neoplasm//Prostate Cancer//Cancer, Prostate//Cancers, Prostate//Prostate Cancers//Cancer of the Prostate//Prostatic Cancer//Cancer, Prostatic//Cancers, Prostatic//Prostatic Cancers//Cancer of Prostate

Expression Detail

GEO ID:	GSE113234
Description:	Circulating microRNAs combined with PSA for an accurate and non-invasive prostate cancer detection
Experimental Design:	Cancer vs Control
Case Disease Type:	Prostate Cancer
Case Disease SubType:	NA
Case Sample:	Prostate Cancer
Control Sample:	Healthy
Number of Case:	60
Number of Control:	27
Number of Samples:	87

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
PRDX2	chr19	12796820	12801800	-
FTL	chr19	48965309	48966879	+
GLRX3	chr10	130136391	130184521	+
INPPL1	chr11	72223701	72239147	+
PTK2B	chr8	27311482	27459391	+
TECR	chr19	14517085	14565980	+
ZFYVE26	chr14	67727374	67816590	-

miRNA targets:

NA

circRNA targets:

NA

lncRNA targets:

NA

Display:

Experiment Detail

GEO ID:	GSE113234
Sample Source:	Blood
Source Fraction:	Plasma
Platform:	GPL19730
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	1972
Sample treatment protocol:	NA
RNA Extract protocol:	Extraction was performed using miRNEasy serum/plasma kit from Qiagen.
RNA library preparation protocol:	Briefly, 4 ul of totRNA were dephosphorylated and denaturated; then a ligation and labeling step with Cy3 was performed

Reference

PMID:	30452625
Title:	Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection
Author:	Mello-Grand M, Gregnanin I, Sacchetto L, Ostano P, Zitella A, Bottoni G, Oderda M, Marra G, Munegato S, Pardini B, Naccarati A, Gasparini M, Gontero P, Chiorino G
Journal:	Carcinogenesis. 2019 Apr 29;40(2):246-253.
Description:	we propose to combine circulating microRNAs (miRs) with PSA, to improve the diagnostic route for PCa