exRNAdisease

Entry Detail

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General Information

Database ID: exR0154861 RNA Name: hsa-miR-641 RNA Type: miRNA Chromosome: chr19 Starnd: - Coordinate: Start Site(bp): 40282603 End Site(bp): 40282626 External Links: hsa-miR-641

Disease Information

Disease Name: Prostate Cancer Disease Category: Cancers MeSH ID: D011471 Type: Neoplasms/Digestive System Neoplasms Alias: Prostatic Neoplasms//Prostate Neoplasms//Neoplasms, Prostate//Neoplasm, Prostate//Prostate Neoplasm//Neoplasms, Prostatic//Neoplasm, Prostatic//Prostatic Neoplasm//Prostate Cancer//Cancer, Prostate//Cancers, Prostate//Prostate Cancers//Cancer of the Prostate//Prostatic Cancer//Cancer, Prostatic//Cancers, Prostatic//Prostatic Cancers//Cancer of Prostate

Expression Detail

GEO ID: GSE113234 Description: Circulating microRNAs combined with PSA for an accurate and non-invasive prostate cancer detection Experimental Design: Cancer vs Control Case Disease Type: Prostate Cancer Case Disease SubType: NA Case Sample: Prostate Cancer Control Sample: Healthy Number of Case: 60 Number of Control: 27 Number of Samples: 87

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AIF1L chr9 131096476 131123152 + AKT2 chr19 40230317 40285536 - C19orf47 chr19 40319536 40348527 - CDKN1A chr6 36676460 36687339 + F11R chr1 160995211 161021343 - FOXN3 chr14 89124871 89619149 - GATAD2B chr1 153789030 153923360 - GCNT2 chr6 10492223 10629368 + GNPTAB chr12 101745499 101830959 - HMGA2 chr12 65824131 65966295 + ICE1 chr5 5420664 5490220 + JPT1 chr17 75135248 75168281 - LSM14A chr19 34172504 34229515 + MED13L chr12 115953872 116277719 - PRSS16 chr6 27247701 27256624 + SETD7 chr4 139495941 139606699 - SOCS3 chr17 78356778 78360077 - SYNJ2BP chr14 70366499 70417090 - SYNJ2BP-COX16 chr14 70326064 70417074 - ZDHHC6 chr10 112424428 112446917 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001085 chr2 191765289 191789319 + hsa_circ_0001168 chr20 47691321 47707559 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC125257.1 chr17 41848518 41851447 - AC239868.1 chr1 149861271 149862504 + AL034397.3 chrX 66015461 66020422 + AL049795.2 chr1 32170733 32176568 + AL355075.4 chr14 20343048 20343685 - DLEU2 chr13 49956670 50125720 - LINC00641 chr14 21200079 21206900 - NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - OIP5-AS1 chr15 41283990 41309737 + SNHG1 chr11 62851984 62855953 - SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE113234 Sample Source: Blood Source Fraction: Plasma Platform: GPL19730 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1972 Sample treatment protocol: NA RNA Extract protocol: Extraction was performed using miRNEasy serum/plasma kit from Qiagen. RNA library preparation protocol: Briefly, 4 ul of totRNA were dephosphorylated and denaturated; then a ligation and labeling step with Cy3 was performed

Reference

PMID: 30452625 Title: Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection Author: Mello-Grand M, Gregnanin I, Sacchetto L, Ostano P, Zitella A, Bottoni G, Oderda M, Marra G, Munegato S, Pardini B, Naccarati A, Gasparini M, Gontero P, Chiorino G Journal: Carcinogenesis. 2019 Apr 29;40(2):246-253. Description: we propose to combine circulating microRNAs (miRs) with PSA, to improve the diagnostic route for PCa