exRNAdisease

Entry Detail

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General Information

Database ID: exR0154966 RNA Name: hsa-miR-760 RNA Type: miRNA Chromosome: chr1 Starnd: + Coordinate: Start Site(bp): 93846880 End Site(bp): 93846899 External Links: hsa-miR-760

Disease Information

Disease Name: Prostate Cancer Disease Category: Cancers MeSH ID: D011471 Type: Neoplasms/Digestive System Neoplasms Alias: Prostatic Neoplasms//Prostate Neoplasms//Neoplasms, Prostate//Neoplasm, Prostate//Prostate Neoplasm//Neoplasms, Prostatic//Neoplasm, Prostatic//Prostatic Neoplasm//Prostate Cancer//Cancer, Prostate//Cancers, Prostate//Prostate Cancers//Cancer of the Prostate//Prostatic Cancer//Cancer, Prostatic//Cancers, Prostatic//Prostatic Cancers//Cancer of Prostate

Expression Detail

GEO ID: GSE113234 Description: Circulating microRNAs combined with PSA for an accurate and non-invasive prostate cancer detection Experimental Design: Cancer vs Control Case Disease Type: Prostate Cancer Case Disease SubType: NA Case Sample: Prostate Cancer Control Sample: Healthy Number of Case: 60 Number of Control: 27 Number of Samples: 87

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABL1 chr9 130713016 130887675 + ACVR1B chr12 51951699 51997078 + ARID3B chr15 74541177 74598131 + C6orf89 chr6 36871870 36928964 + CHTF8 chr16 69118010 69132578 - DBNDD1 chr16 90004871 90020128 - DDX54 chr12 113157174 113185479 - DMWD chr19 45782947 45792845 - EFTUD2 chr17 44849948 44899445 - ITGA5 chr12 54395261 54419266 - MEF2D chr1 156463727 156500779 - PDCD6 chr5 271621 314974 + PDE8A chr15 84980440 85139145 + PDXK chr21 43719094 43762307 + RAE1 chr20 57351223 57379211 + SLC35B2 chr6 44254096 44257890 - TELO2 chr16 1493344 1510457 + TSPAN14 chr10 80454166 80533124 + WSB2 chr12 118032694 118062430 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000458 chr12 124071293 124074996 + hsa_circ_0000038 chr1 28800065 28802803 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand KCNQ1OT1 chr11 2608328 2699994 - MALAT1 chr11 65497688 65506516 + MIR194-2HG chr11 64889560 64893449 - NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG1 chr11 62851984 62855953 - TUG1 chr22 30969245 30979395 + Display:

Experiment Detail

GEO ID: GSE113234 Sample Source: Blood Source Fraction: Plasma Platform: GPL19730 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1972 Sample treatment protocol: NA RNA Extract protocol: Extraction was performed using miRNEasy serum/plasma kit from Qiagen. RNA library preparation protocol: Briefly, 4 ul of totRNA were dephosphorylated and denaturated; then a ligation and labeling step with Cy3 was performed

Reference

PMID: 30452625 Title: Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection Author: Mello-Grand M, Gregnanin I, Sacchetto L, Ostano P, Zitella A, Bottoni G, Oderda M, Marra G, Munegato S, Pardini B, Naccarati A, Gasparini M, Gontero P, Chiorino G Journal: Carcinogenesis. 2019 Apr 29;40(2):246-253. Description: we propose to combine circulating microRNAs (miRs) with PSA, to improve the diagnostic route for PCa