exRNAdisease

Entry Detail

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General Information

Database ID: exR0155234 RNA Name: hsa-miR-139-5p RNA Type: miRNA Chromosome: chr11 Starnd: - Coordinate: Start Site(bp): 72615102 End Site(bp): 72615124 External Links: hsa-miR-139-5p

Disease Information

Disease Name: Benign Prostatic Hyperplasia Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D011470 Type: Diseases Category/Male Urogenital Diseases Alias: Prostatic Hyperplasia//Hyperplasia, Prostatic//Prostatic Hypertrophy//Adenoma, Prostatic//Adenomas, Prostatic//Prostatic Adenomas//Prostatic Adenoma//Benign Prostatic Hyperplasia//Prostatic Hyperplasia, Benign//Prostatic Hypertrophy, Benign//Benign Prostatic Hypertrophy//Hypertrophy, Benign Prostatic

Expression Detail

GEO ID: GSE113234 Description: Circulating microRNAs combined with PSA for an accurate and non-invasive prostate cancer detection Experimental Design: Cancer vs Control Case Disease Type: Prostate Cancer Case Disease SubType: NA Case Sample: Benign Prostatic Hyperplasia Control Sample: Healthy Number of Case: 60 Number of Control: 27 Number of Samples: 87

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AP3M1 chr10 74120255 74151063 - ARIH1 chr15 72474330 72602987 + FBN2 chr5 128257909 128659185 - ISG20L2 chr1 156721891 156728799 - ITGA3 chr17 50055968 50090481 + JPT2 chr16 1678256 1702280 + KLHL28 chr14 44924319 45042322 - LRP8 chr1 53242364 53328469 - MKLN1 chr7 131110096 131496632 + SLC26A2 chr5 149960758 149993455 + SLC31A1 chr9 113221544 113264492 + TGOLN2 chr2 85318020 85328296 - TPM4 chr19 16067021 16103002 + WIPF2 chr17 40219304 40284136 + YWHAB chr20 44885702 44908532 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC068768.1 chr12 123262060 123262402 + AC084082.1 chr8 66112667 66126632 + AL132655.1 chr20 58833809 58836529 - NEAT1 chr11 65422774 65445540 + NUTM2A-AS1 chr10 87201647 87342612 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE113234 Sample Source: Blood Source Fraction: Plasma Platform: GPL19730 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1972 Sample treatment protocol: NA RNA Extract protocol: Extraction was performed using miRNEasy serum/plasma kit from Qiagen. RNA library preparation protocol: Briefly, 4 ul of totRNA were dephosphorylated and denaturated; then a ligation and labeling step with Cy3 was performed

Reference

PMID: 30452625 Title: Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection Author: Mello-Grand M, Gregnanin I, Sacchetto L, Ostano P, Zitella A, Bottoni G, Oderda M, Marra G, Munegato S, Pardini B, Naccarati A, Gasparini M, Gontero P, Chiorino G Journal: Carcinogenesis. 2019 Apr 29;40(2):246-253. Description: we propose to combine circulating microRNAs (miRs) with PSA, to improve the diagnostic route for PCa