exRNAdisease

Entry Detail

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General Information

Database ID: exR0155243 RNA Name: hsa-miR-144-3p RNA Type: miRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 28861548 End Site(bp): 28861567 External Links: hsa-miR-144-3p

Disease Information

Disease Name: Benign Prostatic Hyperplasia Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D011470 Type: Diseases Category/Male Urogenital Diseases Alias: Prostatic Hyperplasia//Hyperplasia, Prostatic//Prostatic Hypertrophy//Adenoma, Prostatic//Adenomas, Prostatic//Prostatic Adenomas//Prostatic Adenoma//Benign Prostatic Hyperplasia//Prostatic Hyperplasia, Benign//Prostatic Hypertrophy, Benign//Benign Prostatic Hypertrophy//Hypertrophy, Benign Prostatic

Expression Detail

GEO ID: GSE113234 Description: Circulating microRNAs combined with PSA for an accurate and non-invasive prostate cancer detection Experimental Design: Cancer vs Control Case Disease Type: Prostate Cancer Case Disease SubType: NA Case Sample: Benign Prostatic Hyperplasia Control Sample: Healthy Number of Case: 60 Number of Control: 27 Number of Samples: 87

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ANXA2 chr15 60347134 60402883 - ARHGAP18 chr6 129576132 129710177 - CNOT11 chr2 101252886 101270316 + EPHA7 chr6 93240020 93419559 - G3BP2 chr4 75642782 75724525 - GABPB1 chr15 50275392 50355408 - IKZF2 chr2 212999691 213152427 - RAB15 chr14 64945814 64973226 - ROCK2 chr2 11179759 11348330 - SGPP1 chr14 63684216 63728065 - USP47 chr11 11841423 11961887 + ZNF695 chr1 246945547 247008093 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001376 chr3 194169185 194175121 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC010980.2 chr2 222317242 222318653 - AC022167.2 chr16 8848105 8860456 + AC093010.3 chr3 114314501 114329714 - AF254983.1 chr21 10482738 10605716 + ARHGAP27P1-BPTFP1-KPNA2P3 chr17 64749663 64781707 - EBLN3P chr9 37079645 37090928 + HCG11 chr6 26521709 26527404 + LINC00662 chr19 27681072 27794005 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - OTUD6B-AS1 chr8 91059318 91070583 - SDCBP2-AS1 chr20 1325405 1378735 + TUG1 chr22 30969245 30979395 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE113234 Sample Source: Blood Source Fraction: Plasma Platform: GPL19730 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1972 Sample treatment protocol: NA RNA Extract protocol: Extraction was performed using miRNEasy serum/plasma kit from Qiagen. RNA library preparation protocol: Briefly, 4 ul of totRNA were dephosphorylated and denaturated; then a ligation and labeling step with Cy3 was performed

Reference

PMID: 30452625 Title: Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection Author: Mello-Grand M, Gregnanin I, Sacchetto L, Ostano P, Zitella A, Bottoni G, Oderda M, Marra G, Munegato S, Pardini B, Naccarati A, Gasparini M, Gontero P, Chiorino G Journal: Carcinogenesis. 2019 Apr 29;40(2):246-253. Description: we propose to combine circulating microRNAs (miRs) with PSA, to improve the diagnostic route for PCa