exRNAdisease

Entry Detail

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General Information

Database ID: exR0155246 RNA Name: hsa-miR-145-5p RNA Type: miRNA Chromosome: chr5 Starnd: + Coordinate: Start Site(bp): 149430661 End Site(bp): 149430683 External Links: hsa-miR-145-5p

Disease Information

Disease Name: Benign Prostatic Hyperplasia Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D011470 Type: Diseases Category/Male Urogenital Diseases Alias: Prostatic Hyperplasia//Hyperplasia, Prostatic//Prostatic Hypertrophy//Adenoma, Prostatic//Adenomas, Prostatic//Prostatic Adenomas//Prostatic Adenoma//Benign Prostatic Hyperplasia//Prostatic Hyperplasia, Benign//Prostatic Hypertrophy, Benign//Benign Prostatic Hypertrophy//Hypertrophy, Benign Prostatic

Expression Detail

GEO ID: GSE113234 Description: Circulating microRNAs combined with PSA for an accurate and non-invasive prostate cancer detection Experimental Design: Cancer vs Control Case Disease Type: Prostate Cancer Case Disease SubType: NA Case Sample: Benign Prostatic Hyperplasia Control Sample: Healthy Number of Case: 60 Number of Control: 27 Number of Samples: 87

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACBD5 chr10 27195214 27242130 - ATP9A chr20 51596514 51768390 - BAZ1B chr7 73440406 73522293 - CARMIL1 chr6 25279078 25620530 + CCNJ chr10 96043394 96060870 + MYRF chr11 61752642 61788518 + PLEKHM1 chr17 45435900 45490749 - PPP1R9B chr17 50133737 50150677 - RAD23B chr9 107283137 107332192 + ZNF28 chr19 52797408 52857600 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001454 chr4 154524454 154533552 + hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0001731 chr7 100731990 100738448 + hsa_circ_0001492 chr5 65284462 65290692 + hsa_circ_0001414 chr4 56277780 56284152 + hsa_circ_0000943 chr19 47421744 47440665 + hsa_circ_0001168 chr20 47691321 47707559 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC006064.5 chr12 6510275 6510522 + AC016876.2 chr17 7581964 7584086 - AC023509.1 chr12 53441741 53467528 + AC105339.2 chr15 82752884 82757208 + AC144548.1 chr12 110387463 110445548 - AL031282.2 chr1 1702736 1737688 - JPX chrX 73944182 74070408 + KCNQ1OT1 chr11 2608328 2699994 - LINC00852 chr3 10284419 10285746 + MALAT1 chr11 65497688 65506516 + MEG3 chr14 100779410 100861031 + SNHG1 chr11 62851984 62855953 - TUG1 chr22 30969245 30979395 + Display:

Experiment Detail

GEO ID: GSE113234 Sample Source: Blood Source Fraction: Plasma Platform: GPL19730 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1972 Sample treatment protocol: NA RNA Extract protocol: Extraction was performed using miRNEasy serum/plasma kit from Qiagen. RNA library preparation protocol: Briefly, 4 ul of totRNA were dephosphorylated and denaturated; then a ligation and labeling step with Cy3 was performed

Reference

PMID: 30452625 Title: Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection Author: Mello-Grand M, Gregnanin I, Sacchetto L, Ostano P, Zitella A, Bottoni G, Oderda M, Marra G, Munegato S, Pardini B, Naccarati A, Gasparini M, Gontero P, Chiorino G Journal: Carcinogenesis. 2019 Apr 29;40(2):246-253. Description: we propose to combine circulating microRNAs (miRs) with PSA, to improve the diagnostic route for PCa