exRNAdisease

Entry Detail

---



General Information

Database ID: exR0155264 RNA Name: hsa-miR-150-5p RNA Type: miRNA Chromosome: chr19 Starnd: - Coordinate: Start Site(bp): 49500832 End Site(bp): 49500853 External Links: hsa-miR-150-5p

Disease Information

Disease Name: Benign Prostatic Hyperplasia Disease Category: Urogenital Diseases and Pregnancy Complications MeSH ID: D011470 Type: Diseases Category/Male Urogenital Diseases Alias: Prostatic Hyperplasia//Hyperplasia, Prostatic//Prostatic Hypertrophy//Adenoma, Prostatic//Adenomas, Prostatic//Prostatic Adenomas//Prostatic Adenoma//Benign Prostatic Hyperplasia//Prostatic Hyperplasia, Benign//Prostatic Hypertrophy, Benign//Benign Prostatic Hypertrophy//Hypertrophy, Benign Prostatic

Expression Detail

GEO ID: GSE113234 Description: Circulating microRNAs combined with PSA for an accurate and non-invasive prostate cancer detection Experimental Design: Cancer vs Control Case Disease Type: Prostate Cancer Case Disease SubType: NA Case Sample: Benign Prostatic Hyperplasia Control Sample: Healthy Number of Case: 60 Number of Control: 27 Number of Samples: 87

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ADIPOR2 chr12 1688574 1788674 + CDKN1B chr12 12715058 12722369 + HNRNPH1 chr5 179614178 179634784 - HSPG2 chr1 21822244 21937310 - NF2 chr22 29603556 29698598 + PACS1 chr11 66070272 66244744 + PHC3 chr3 170086732 170181749 - SYVN1 chr11 65121780 65134533 - ZHX3 chr20 41178448 41317672 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001387 chr4 1902352 1936989 + hsa_circ_0000552 chr14 71880664 71948928 + hsa_circ_0001146 chr20 34241449 34246936 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC021078.1 chr5 149494314 149504670 - AL603839.3 chr1 40493157 40508661 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - ZFAS1 chr20 49278178 49299600 + Display:

Experiment Detail

GEO ID: GSE113234 Sample Source: Blood Source Fraction: Plasma Platform: GPL19730 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 1972 Sample treatment protocol: NA RNA Extract protocol: Extraction was performed using miRNEasy serum/plasma kit from Qiagen. RNA library preparation protocol: Briefly, 4 ul of totRNA were dephosphorylated and denaturated; then a ligation and labeling step with Cy3 was performed

Reference

PMID: 30452625 Title: Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection Author: Mello-Grand M, Gregnanin I, Sacchetto L, Ostano P, Zitella A, Bottoni G, Oderda M, Marra G, Munegato S, Pardini B, Naccarati A, Gasparini M, Gontero P, Chiorino G Journal: Carcinogenesis. 2019 Apr 29;40(2):246-253. Description: we propose to combine circulating microRNAs (miRs) with PSA, to improve the diagnostic route for PCa