Entry Detail



General Information

Database ID:exR0192495
RNA Name:hsa-miR-103a-3p
RNA Type:miRNA
Chromosome:chr5
Starnd:-
Coordinate:
Start Site(bp):168560904End Site(bp):168560926
External Links:hsa-miR-103a-3p



Disease Information

Disease Name:Epilepsy
Disease Category:Nervous System Diseases
MeSH ID:D004827
Type:Diseases Category/Nervous System Diseases
Alias:Epilepsies//Seizure Disorder//Seizure Disorders//Awakening Epilepsy//Epilepsy, Awakening//Epilepsy, Cryptogenic//Cryptogenic Epilepsies//Cryptogenic Epilepsy//Epilepsies, Cryptogenic//Aura//Auras



Expression Detail

GEO ID:GSE114697
Description:Dual-center, dual-platform microRNA profiling identifies plasma biomarkers of adult temporal lobe epilepsy (Beaumont)
Experimental Design:Disease vs Control
Case Disease Type:Epilepsy
Case Disease SubType:NA
Case Sample:Epilepsy
Control Sample:Control
Number of Case:32
Number of Control:16
Number of Samples:48





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
RCCD1
chr15
90954870
90963125
+
CA12
chr15
63321378
63381846
-
AMER1
chrX
64185117
64205708
-
PLPP6
chr9
4662294
4665258
+
ERG28
chr14
75649791
75660876
-
SCAMP4
chr19
1905372
1926013
+
DPP3
chr11
66480013
66509657
+
AC011455.2
chr19
38915404
38949855
-
UBN1
chr16
4846665
4882401
+
TMX2
chr11
57712593
57740973
+
RNF157
chr17
76142465
76240493
-
NAA60
chr16
3443649
3486953
+
MRPS2
chr9
135499984
135504673
+
TSPYL2
chrX
53082367
53088540
+
KLHL21
chr1
6590724
6614607
-
TUBA1B
chr12
49127782
49131397
-
STEAP3
chr2
119223831
119265652
+
MRPL3
chr3
131462212
131502983
-
STK16
chr2
219245455
219250337
+
ABCF2
chr7
151207837
151227166
-
RPS6KA3
chrX
20149911
20267519
-
DCAF7
chr17
63550477
63594279
+
CNN2
chr19
1026586
1039068
+
SRPK1
chr6
35832966
35921342
-
ZNF697
chr1
119619377
119648266
-
LYSMD2
chr15
51723011
51751585
-
PODXL
chr7
131500262
131558217
-
EBP
chrX
48521799
48528716
+
RPS14
chr5
150442635
150449739
-
PKM
chr15
72199029
72231822
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000712
chr16
68208276
68225678
+
hsa_circ_0001723
chr7
91924202
91948826
+
hsa_circ_0001495
chr5
68470703
68471364
+
hsa_circ_0001168
chr20
47691321
47707559
+
hsa_circ_0000652
chr15
90984737
90986710
+
hsa_circ_0001472
chr5
36953719
36976504
+
hsa_circ_0001164
chr20
45891031
45923523
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC003092.1
chr7
94022833
94066661
+
AC018521.1
chr17
47945424
47981736
+
AC021078.1
chr5
149494314
149504670
-
AC021092.1
chr19
44103007
44113183
-
AC093297.2
chr5
44826076
44828592
+
AL137127.1
chr1
19072110
19075511
-
FGD5-AS1
chr3
14920347
14948424
-
H19
chr11
1995176
2001470
-
LINC00294
chr11
33076149
33079454
+
LINC00662
chr19
27681072
27794005
-
LINC02035
chr3
122886941
122892416
+
MIR503HG
chrX
134543119
134546642
-
NEAT1
chr11
65422774
65445540
+
NUTM2A-AS1
chr10
87201647
87342612
-
NUTM2B-AS1
chr10
79661394
79826594
-
STAG3L5P-PVRIG2P-PILRB
chr7
100336104
100367831
+
TMEM147-AS1
chr19
35540738
35546029
-
TTC28-AS1
chr22
27919376
28008581
+
TTN-AS1
chr2
178521183
178779963
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE114697
Sample Source:Blood
Source Fraction:Plasma
Platform:GPL22992
Method:RT-PCR array
Num of detected RNA Type:1
Num of detected RNAs of this Type:78
Sample treatment protocol:NA
RNA Extract protocol:Total RNA was extracted from 200 ul of plasma using the miRCURY RNA isolation kit-biofluid (Exiqon).
RNA library preparation protocol:3 ul of total RNA was processed by reverse transcriptase and mixed with TaqMan OpenArray Real-Time PCR Master mix (1:1).



Reference

PMID:30396857
Title:Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsy
Author:Raoof R, Bauer S, El Naggar H, Connolly NMC, Brennan GP, Brindley E, Hill T, McArdle H, Spain E, Forster RJ, Prehn JHM, Hamer H, Delanty N, Rosenow F, Mooney C, Henshall DC
Journal:EBioMedicine. 2018 Dec;38:127-141.
Description:Using a case-control design, we collected plasma samples from video-electroencephalogram-monitored adult TLE patients at epilepsy specialist centers in two countries, performed genome-wide PCR-based and RNA sequencing during the discovery phase and validated findings in a large (>) cohort of samples that included patients with psychogenic non-epileptic seizures (PNES)