exRNAdisease

Entry Detail

General Information

Database ID:

exR0192507

RNA Name:

hsa-miR-142-3p

RNA Type:

miRNA

Chromosome:

chr17

Starnd:

-

Coordinate:

Start Site(bp):

58331245

End Site(bp):

58331267

External Links:

Disease Information

Disease Name:	Epilepsy
Disease Category:	Nervous System Diseases
MeSH ID:	D004827
Type:	Diseases Category/Nervous System Diseases
Alias:	Epilepsies//Seizure Disorder//Seizure Disorders//Awakening Epilepsy//Epilepsy, Awakening//Epilepsy, Cryptogenic//Cryptogenic Epilepsies//Cryptogenic Epilepsy//Epilepsies, Cryptogenic//Aura//Auras

Expression Detail

GEO ID:	GSE114697
Description:	Dual-center, dual-platform microRNA profiling identifies plasma biomarkers of adult temporal lobe epilepsy (Beaumont)
Experimental Design:	Disease vs Control
Case Disease Type:	Epilepsy
Case Disease SubType:	NA
Case Sample:	Epilepsy
Control Sample:	Control
Number of Case:	32
Number of Control:	16
Number of Samples:	48

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
BLOC1S6	chr15	45587214	45615945	+
BOD1	chr5	173607145	173616659	-
CUL5	chr11	108008898	108107761	+
ETFRF1	chr12	25195216	25209645	+
SEMA7A	chr15	74409289	74433958	-
TNRC6B	chr22	40044817	40335808	+
ZNF676	chr19	22179089	22215801	-
AL139011.2	chr1	160216800	160285130	-
B2M	chr15	44711487	44718877	+
CCDC126	chr7	23597382	23644708	+
EEF1A1	chr6	73515750	73523797	-
MAST2	chr1	45786987	46036122	+
MBD3	chr19	1573596	1592865	-
MRPL18	chr6	159789812	159798436	+
NDUFA2	chr5	140638740	140647785	-
PEX19	chr1	160276812	160286348	-
PRDX1	chr1	45511036	45523047	-
RPL27	chr17	42998273	43002959	+
SLC35F5	chr2	113705011	113756693	-
SPDL1	chr5	169583636	169604778	+
TMSB4X	chrX	12975110	12977227	+
VPS53	chr17	508668	721717	-

miRNA targets:

NA

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0000120	chr1	117944807	118009049	+
hsa_circ_0001387	chr4	1902352	1936989	+

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC004687.1	chr17	58330884	58332508	-
AC011815.1	chr18	35280867	35290201	-
AC126365.1	chr17	20788071	20789584	+
FGD5-AS1	chr3	14920347	14948424	-
MALAT1	chr11	65497688	65506516	+
NEAT1	chr11	65422774	65445540	+
AC138761.1	chr17	22266395	22288301	+

Display:

Experiment Detail

GEO ID:	GSE114697
Sample Source:	Blood
Source Fraction:	Plasma
Platform:	GPL22992
Method:	RT-PCR array
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	78
Sample treatment protocol:	NA
RNA Extract protocol:	Total RNA was extracted from 200 ul of plasma using the miRCURY RNA isolation kit-biofluid (Exiqon).
RNA library preparation protocol:	3 ul of total RNA was processed by reverse transcriptase and mixed with TaqMan OpenArray Real-Time PCR Master mix (1:1).

Reference

PMID:	30396857
Title:	Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsy
Author:	Raoof R, Bauer S, El Naggar H, Connolly NMC, Brennan GP, Brindley E, Hill T, McArdle H, Spain E, Forster RJ, Prehn JHM, Hamer H, Delanty N, Rosenow F, Mooney C, Henshall DC
Journal:	EBioMedicine. 2018 Dec;38:127-141.
Description:	Using a case-control design, we collected plasma samples from video-electroencephalogram-monitored adult TLE patients at epilepsy specialist centers in two countries, performed genome-wide PCR-based and RNA sequencing during the discovery phase and validated findings in a large (>) cohort of samples that included patients with psychogenic non-epileptic seizures (PNES)