exRNAdisease

Entry Detail

General Information

Database ID:

exR0192529

RNA Name:

hsa-miR-221-3p

RNA Type:

miRNA

Chromosome:

chrX

Starnd:

-

Coordinate:

Start Site(bp):

45746180

End Site(bp):

45746202

External Links:

Disease Information

Disease Name:	Epilepsy
Disease Category:	Nervous System Diseases
MeSH ID:	D004827
Type:	Diseases Category/Nervous System Diseases
Alias:	Epilepsies//Seizure Disorder//Seizure Disorders//Awakening Epilepsy//Epilepsy, Awakening//Epilepsy, Cryptogenic//Cryptogenic Epilepsies//Cryptogenic Epilepsy//Epilepsies, Cryptogenic//Aura//Auras

Expression Detail

GEO ID:	GSE114697
Description:	Dual-center, dual-platform microRNA profiling identifies plasma biomarkers of adult temporal lobe epilepsy (Beaumont)
Experimental Design:	Disease vs Control
Case Disease Type:	Epilepsy
Case Disease SubType:	NA
Case Sample:	Epilepsy
Control Sample:	Control
Number of Case:	32
Number of Control:	16
Number of Samples:	48

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
ACVR2B	chr3	38453890	38493142	+
AP3M1	chr10	74120255	74151063	-
DNAJC14	chr12	55820960	55830824	-
EFNA1	chr1	155127876	155134899	+
KDSR	chr18	63327726	63367228	-
MPZL1	chr1	167721192	167791919	+
PPIL1	chr6	36854827	36874803	-
TBL1X	chrX	9463295	9741037	+
TUB	chr11	8019244	8106112	+
ZBTB5	chr9	37438102	37465450	-
DDIT4	chr10	72273924	72276036	+
FUS	chr16	31180110	31194871	+
MAPRE1	chr20	32819954	32850405	+
RIPOR2	chr6	24804282	25042170	-
SP4	chr7	21428043	21514822	+
TUBA1B	chr12	49127782	49131397	-
ZNF649	chr19	51889235	51905040	-

miRNA targets:

NA

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0001247	chr22	46125304	46136418	+
hsa_circ_0000670	chr16	9199043	9199243	+

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC020978.7	chr16	68224713	68227734	+
AC022150.4	chr19	52650437	52653284	-
ARHGAP27P1-BPTFP1-KPNA2P3	chr17	64749663	64781707	-
GAS5	chr1	173858559	173868882	-
NEAT1	chr11	65422774	65445540	+
TUG1	chr22	30969245	30979395	+
TYMSOS	chr18	630886	658340	-

Display:

Experiment Detail

GEO ID:	GSE114697
Sample Source:	Blood
Source Fraction:	Plasma
Platform:	GPL22992
Method:	RT-PCR array
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	78
Sample treatment protocol:	NA
RNA Extract protocol:	Total RNA was extracted from 200 ul of plasma using the miRCURY RNA isolation kit-biofluid (Exiqon).
RNA library preparation protocol:	3 ul of total RNA was processed by reverse transcriptase and mixed with TaqMan OpenArray Real-Time PCR Master mix (1:1).

Reference

PMID:	30396857
Title:	Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsy
Author:	Raoof R, Bauer S, El Naggar H, Connolly NMC, Brennan GP, Brindley E, Hill T, McArdle H, Spain E, Forster RJ, Prehn JHM, Hamer H, Delanty N, Rosenow F, Mooney C, Henshall DC
Journal:	EBioMedicine. 2018 Dec;38:127-141.
Description:	Using a case-control design, we collected plasma samples from video-electroencephalogram-monitored adult TLE patients at epilepsy specialist centers in two countries, performed genome-wide PCR-based and RNA sequencing during the discovery phase and validated findings in a large (>) cohort of samples that included patients with psychogenic non-epileptic seizures (PNES)