exRNAdisease

Entry Detail

General Information

Database ID:

exR0192536

RNA Name:

hsa-miR-26b-5p

RNA Type:

miRNA

Chromosome:

chr2

Starnd:

+

Coordinate:

Start Site(bp):

218402657

End Site(bp):

218402677

External Links:

Disease Information

Disease Name:	Epilepsy
Disease Category:	Nervous System Diseases
MeSH ID:	D004827
Type:	Diseases Category/Nervous System Diseases
Alias:	Epilepsies//Seizure Disorder//Seizure Disorders//Awakening Epilepsy//Epilepsy, Awakening//Epilepsy, Cryptogenic//Cryptogenic Epilepsies//Cryptogenic Epilepsy//Epilepsies, Cryptogenic//Aura//Auras

Expression Detail

GEO ID:	GSE114697
Description:	Dual-center, dual-platform microRNA profiling identifies plasma biomarkers of adult temporal lobe epilepsy (Beaumont)
Experimental Design:	Disease vs Control
Case Disease Type:	Epilepsy
Case Disease SubType:	NA
Case Sample:	Epilepsy
Control Sample:	Control
Number of Case:	32
Number of Control:	16
Number of Samples:	48

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
CDK12	chr17	39461486	39564907	+
GRB10	chr7	50590063	50793462	-
NID1	chr1	235975830	236065109	-
SLC26A2	chr5	149960758	149993455	+
ATP5F1B	chr12	56638175	56645984	-

miRNA targets:

NA

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0000120	chr1	117944807	118009049	+
hsa_circ_0000943	chr19	47421744	47440665	+
hsa_circ_0001146	chr20	34241449	34246936	-

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC005082.1	chr7	23205787	23208045	+
AC016026.1	chr22	17787652	17811497	-
AC068768.1	chr12	123262060	123262402	+
AC144548.1	chr12	110387463	110445548	-
AL122035.1	chr14	64422935	64448557	-
AL137127.1	chr1	19072110	19075511	-
AL358472.3	chr1	153966516	153966930	+
ARHGAP27P1-BPTFP1-KPNA2P3	chr17	64749663	64781707	-
GAS5	chr1	173858559	173868882	-
HCG11	chr6	26521709	26527404	+
LINC00205	chr21	45288050	45297806	+
LINC00240	chr6	26956932	27059749	+
MALAT1	chr11	65497688	65506516	+
NEAT1	chr11	65422774	65445540	+
NORAD	chr20	36045618	36051018	-
RRN3P2	chr16	29074976	29116718	+
SNHG5	chr6	85650491	85678932	-
SNHG6	chr8	66921684	66926398	-
TUG1	chr22	30969245	30979395	+

Display:

Experiment Detail

GEO ID:	GSE114697
Sample Source:	Blood
Source Fraction:	Plasma
Platform:	GPL22992
Method:	RT-PCR array
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	78
Sample treatment protocol:	NA
RNA Extract protocol:	Total RNA was extracted from 200 ul of plasma using the miRCURY RNA isolation kit-biofluid (Exiqon).
RNA library preparation protocol:	3 ul of total RNA was processed by reverse transcriptase and mixed with TaqMan OpenArray Real-Time PCR Master mix (1:1).

Reference

PMID:	30396857
Title:	Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsy
Author:	Raoof R, Bauer S, El Naggar H, Connolly NMC, Brennan GP, Brindley E, Hill T, McArdle H, Spain E, Forster RJ, Prehn JHM, Hamer H, Delanty N, Rosenow F, Mooney C, Henshall DC
Journal:	EBioMedicine. 2018 Dec;38:127-141.
Description:	Using a case-control design, we collected plasma samples from video-electroencephalogram-monitored adult TLE patients at epilepsy specialist centers in two countries, performed genome-wide PCR-based and RNA sequencing during the discovery phase and validated findings in a large (>) cohort of samples that included patients with psychogenic non-epileptic seizures (PNES)