exRNAdisease

Entry Detail

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General Information

Database ID: exR0192542 RNA Name: hsa-miR-301a-3p RNA Type: miRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 59151149 End Site(bp): 59151171 External Links: hsa-miR-301a-3p

Disease Information

Disease Name: Epilepsy Disease Category: Nervous System Diseases MeSH ID: D004827 Type: Diseases Category/Nervous System Diseases Alias: Epilepsies//Seizure Disorder//Seizure Disorders//Awakening Epilepsy//Epilepsy, Awakening//Epilepsy, Cryptogenic//Cryptogenic Epilepsies//Cryptogenic Epilepsy//Epilepsies, Cryptogenic//Aura//Auras

Expression Detail

GEO ID: GSE114697 Description: Dual-center, dual-platform microRNA profiling identifies plasma biomarkers of adult temporal lobe epilepsy (Beaumont) Experimental Design: Disease vs Control Case Disease Type: Epilepsy Case Disease SubType: NA Case Sample: Epilepsy Control Sample: Control Number of Case: 32 Number of Control: 16 Number of Samples: 48

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ALDH3A2 chr17 19648136 19685760 + TNFRSF1B chr1 12166991 12209228 + CAMTA1 chr1 6785454 7769706 + CPEB4 chr5 173888349 173961980 + ZDHHC7 chr16 84974181 85011535 - STARD13 chr13 33103137 33350630 - APCDD1 chr18 10454635 10489949 + HABP4 chr9 96450169 96491336 + TBC1D5 chr3 17157162 18444817 - ZNF12 chr7 6688433 6706947 - PTEN chr10 87863625 87971930 + NPTX1 chr17 80466834 80477843 - APOL6 chr22 35648446 35668404 + CD151 chr11 832887 839831 + PPP1R9A chr7 94907202 95296415 + KIAA0232 chr4 6781375 6884170 + ZNF594 chr17 5179535 5191868 - LIPA chr10 89213569 89414557 - LYSMD2 chr15 51723011 51751585 - MLPH chr2 237485428 237555322 + EMP1 chr12 13196723 13219941 + KLF4 chr9 107484852 107490482 - RTN4 chr2 54972187 55112621 - SCAF11 chr12 45919131 45992120 - RNF11 chr1 51236273 51273447 + XXYLT1 chr3 195068284 195271159 - SHANK2 chr11 70467856 71252577 - NSD2 chr4 1871393 1982207 + SLC7A5 chr16 87830023 87869507 - MTMR9 chr8 11284816 11328146 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000591 chr15 41961025 41962156 + hsa_circ_0001454 chr4 154524454 154533552 + hsa_circ_0000384 chr12 27867712 27877119 + hsa_circ_0001723 chr7 91924202 91948826 + hsa_circ_0000892 chr19 11941431 12014514 + hsa_circ_0001605 chr6 42903447 42905047 + hsa_circ_0000155 chr1 168007608 168014465 + hsa_circ_0001495 chr5 68470703 68471364 + hsa_circ_0000943 chr19 47421744 47440665 + hsa_circ_0000018 chr1 15860731 15863309 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC011503.2 chr19 23927788 23929287 + AC021092.1 chr19 44103007 44113183 - AC135050.6 chr16 31122235 31124064 + AC234582.1 chr1 155195004 155205495 + AL031595.3 chr22 44139365 44153626 + AL049840.4 chr14 103694516 103695050 - AL158206.1 chr9 19453209 19455173 + AL158825.2 chr9 75009828 75016036 - AL603839.3 chr1 40493157 40508661 - CKMT2-AS1 chr5 81201341 81301565 - H19 chr11 1995176 2001470 - HAGLR chr2 176164051 176188958 - KCNQ1OT1 chr11 2608328 2699994 - LINC01089 chr12 121795267 121803906 - MIR17HG chr13 91347820 91354579 + NEAT1 chr11 65422774 65445540 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE114697 Sample Source: Blood Source Fraction: Plasma Platform: GPL22992 Method: RT-PCR array Num of detected RNA Type: 1 Num of detected RNAs of this Type: 78 Sample treatment protocol: NA RNA Extract protocol: Total RNA was extracted from 200 ul of plasma using the miRCURY RNA isolation kit-biofluid (Exiqon). RNA library preparation protocol: 3 ul of total RNA was processed by reverse transcriptase and mixed with TaqMan OpenArray Real-Time PCR Master mix (1:1).

Reference

PMID: 30396857 Title: Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsy Author: Raoof R, Bauer S, El Naggar H, Connolly NMC, Brennan GP, Brindley E, Hill T, McArdle H, Spain E, Forster RJ, Prehn JHM, Hamer H, Delanty N, Rosenow F, Mooney C, Henshall DC Journal: EBioMedicine. 2018 Dec;38:127-141. Description: Using a case-control design, we collected plasma samples from video-electroencephalogram-monitored adult TLE patients at epilepsy specialist centers in two countries, performed genome-wide PCR-based and RNA sequencing during the discovery phase and validated findings in a large (>) cohort of samples that included patients with psychogenic non-epileptic seizures (PNES)