exRNAdisease

Entry Detail

General Information

Database ID:

exR0192545

RNA Name:

hsa-miR-30c-5p

RNA Type:

miRNA

Chromosome:

chr6

Starnd:

-

Coordinate:

Start Site(bp):

71377003

End Site(bp):

71377025

External Links:

Disease Information

Disease Name:	Epilepsy
Disease Category:	Nervous System Diseases
MeSH ID:	D004827
Type:	Diseases Category/Nervous System Diseases
Alias:	Epilepsies//Seizure Disorder//Seizure Disorders//Awakening Epilepsy//Epilepsy, Awakening//Epilepsy, Cryptogenic//Cryptogenic Epilepsies//Cryptogenic Epilepsy//Epilepsies, Cryptogenic//Aura//Auras

Expression Detail

GEO ID:	GSE114697
Description:	Dual-center, dual-platform microRNA profiling identifies plasma biomarkers of adult temporal lobe epilepsy (Beaumont)
Experimental Design:	Disease vs Control
Case Disease Type:	Epilepsy
Case Disease SubType:	NA
Case Sample:	Epilepsy
Control Sample:	Control
Number of Case:	32
Number of Control:	16
Number of Samples:	48

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
ARRDC4	chr15	97960703	97973833	+
CLN8	chr8	1755778	1801711	+
GIGYF1	chr7	100679507	100694037	-
PGK1	chrX	77910739	78129295	+
UTP4	chr16	69131291	69231130	+

miRNA targets:

NA

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0000540	chr14	55799534	55821940	+
hsa_circ_0000384	chr12	27867712	27877119	+
hsa_circ_0001168	chr20	47691321	47707559	+
hsa_circ_0001146	chr20	34241449	34246936	-

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC005034.3	chr2	75697583	75697996	+
AC008124.1	chr12	45718046	45727775	-
AC012236.1	chr15	31221999	31230838	-
AC021078.1	chr5	149494314	149504670	-
AL049840.4	chr14	103694516	103695050	-
AL137129.1	chr14	61734138	61776260	+
DLEU2	chr13	49956670	50125720	-
MALAT1	chr11	65497688	65506516	+
NEAT1	chr11	65422774	65445540	+
NORAD	chr20	36045618	36051018	-
OIP5-AS1	chr15	41283990	41309737	+
SNHG16	chr17	76557764	76565348	+
XIST	chrX	73820649	73852723	-

Display:

Experiment Detail

GEO ID:	GSE114697
Sample Source:	Blood
Source Fraction:	Plasma
Platform:	GPL22992
Method:	RT-PCR array
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	78
Sample treatment protocol:	NA
RNA Extract protocol:	Total RNA was extracted from 200 ul of plasma using the miRCURY RNA isolation kit-biofluid (Exiqon).
RNA library preparation protocol:	3 ul of total RNA was processed by reverse transcriptase and mixed with TaqMan OpenArray Real-Time PCR Master mix (1:1).

Reference

PMID:	30396857
Title:	Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsy
Author:	Raoof R, Bauer S, El Naggar H, Connolly NMC, Brennan GP, Brindley E, Hill T, McArdle H, Spain E, Forster RJ, Prehn JHM, Hamer H, Delanty N, Rosenow F, Mooney C, Henshall DC
Journal:	EBioMedicine. 2018 Dec;38:127-141.
Description:	Using a case-control design, we collected plasma samples from video-electroencephalogram-monitored adult TLE patients at epilepsy specialist centers in two countries, performed genome-wide PCR-based and RNA sequencing during the discovery phase and validated findings in a large (>) cohort of samples that included patients with psychogenic non-epileptic seizures (PNES)