exRNAdisease

Entry Detail

General Information

Database ID:

exR0192549

RNA Name:

hsa-miR-324-5p

RNA Type:

miRNA

Chromosome:

chr17

Starnd:

-

Coordinate:

Start Site(bp):

7223343

End Site(bp):

7223364

External Links:

Disease Information

Disease Name:	Epilepsy
Disease Category:	Nervous System Diseases
MeSH ID:	D004827
Type:	Diseases Category/Nervous System Diseases
Alias:	Epilepsies//Seizure Disorder//Seizure Disorders//Awakening Epilepsy//Epilepsy, Awakening//Epilepsy, Cryptogenic//Cryptogenic Epilepsies//Cryptogenic Epilepsy//Epilepsies, Cryptogenic//Aura//Auras

Expression Detail

GEO ID:	GSE114697
Description:	Dual-center, dual-platform microRNA profiling identifies plasma biomarkers of adult temporal lobe epilepsy (Beaumont)
Experimental Design:	Disease vs Control
Case Disease Type:	Epilepsy
Case Disease SubType:	NA
Case Sample:	Epilepsy
Control Sample:	Control
Number of Case:	32
Number of Control:	16
Number of Samples:	48

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AGTRAP	chr1	11736084	11754802	+
BASP1	chr5	17065598	17276843	+
CA12	chr15	63321378	63381846	-
NRIP1	chr21	14961235	15065936	-
PYGO2	chr1	154957026	154963853	-
SHPK	chr17	3608240	3636250	-

miRNA targets:

NA

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0001731	chr7	100731990	100738448	+
hsa_circ_0000987	chr2	30748452	30756180	+

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC007952.4	chr17	19112000	19112636	-
AC026362.1	chr12	122975320	122982907	+
AL137127.1	chr1	19072110	19075511	-
HCG18	chr6	30286690	30327382	-
NEAT1	chr11	65422774	65445540	+
XIST	chrX	73820649	73852723	-
Z93241.1	chr22	42615244	42615907	+

Display:

Experiment Detail

GEO ID:	GSE114697
Sample Source:	Blood
Source Fraction:	Plasma
Platform:	GPL22992
Method:	RT-PCR array
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	78
Sample treatment protocol:	NA
RNA Extract protocol:	Total RNA was extracted from 200 ul of plasma using the miRCURY RNA isolation kit-biofluid (Exiqon).
RNA library preparation protocol:	3 ul of total RNA was processed by reverse transcriptase and mixed with TaqMan OpenArray Real-Time PCR Master mix (1:1).

Reference

PMID:	30396857
Title:	Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsy
Author:	Raoof R, Bauer S, El Naggar H, Connolly NMC, Brennan GP, Brindley E, Hill T, McArdle H, Spain E, Forster RJ, Prehn JHM, Hamer H, Delanty N, Rosenow F, Mooney C, Henshall DC
Journal:	EBioMedicine. 2018 Dec;38:127-141.
Description:	Using a case-control design, we collected plasma samples from video-electroencephalogram-monitored adult TLE patients at epilepsy specialist centers in two countries, performed genome-wide PCR-based and RNA sequencing during the discovery phase and validated findings in a large (>) cohort of samples that included patients with psychogenic non-epileptic seizures (PNES)