exRNAdisease

Entry Detail

General Information

Database ID:

exR0192551

RNA Name:

hsa-miR-331-3p

RNA Type:

miRNA

Chromosome:

chr12

Starnd:

+

Coordinate:

Start Site(bp):

95308480

End Site(bp):

95308500

External Links:

Disease Information

Disease Name:	Epilepsy
Disease Category:	Nervous System Diseases
MeSH ID:	D004827
Type:	Diseases Category/Nervous System Diseases
Alias:	Epilepsies//Seizure Disorder//Seizure Disorders//Awakening Epilepsy//Epilepsy, Awakening//Epilepsy, Cryptogenic//Cryptogenic Epilepsies//Cryptogenic Epilepsy//Epilepsies, Cryptogenic//Aura//Auras

Expression Detail

GEO ID:	GSE114697
Description:	Dual-center, dual-platform microRNA profiling identifies plasma biomarkers of adult temporal lobe epilepsy (Beaumont)
Experimental Design:	Disease vs Control
Case Disease Type:	Epilepsy
Case Disease SubType:	NA
Case Sample:	Epilepsy
Control Sample:	Control
Number of Case:	32
Number of Control:	16
Number of Samples:	48

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
ATXN7L3	chr17	44191805	44200113	-
DAG1	chr3	49468703	49535618	+
ITGA5	chr12	54395261	54419266	-
NACC1	chr19	13116862	13141147	+
NDST1	chr5	150485818	150558211	+
RPUSD1	chr16	784974	788397	-
SDC1	chr2	20200797	20225433	-
SRF	chr6	43171269	43181506	+
TRABD	chr22	50185915	50199598	+
VCP	chr9	35056064	35072627	-

miRNA targets:

NA

circRNA targets:

circRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa_circ_0001866	chr9	86293355	86297981	-
hsa_circ_0001865	chr9	86292641	86293514	-

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC005332.7	chr17	68188547	68189165	+
AC016876.2	chr17	7581964	7584086	-
H19	chr11	1995176	2001470	-
KCNQ1OT1	chr11	2608328	2699994	-
NEAT1	chr11	65422774	65445540	+
PDCD4-AS1	chr10	110869868	110872233	-
SNHG7	chr9	136721366	136728184	-
VPS9D1-AS1	chr16	89711856	89718165	+
XIST	chrX	73820649	73852723	-

Display:

Experiment Detail

GEO ID:	GSE114697
Sample Source:	Blood
Source Fraction:	Plasma
Platform:	GPL22992
Method:	RT-PCR array
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	78
Sample treatment protocol:	NA
RNA Extract protocol:	Total RNA was extracted from 200 ul of plasma using the miRCURY RNA isolation kit-biofluid (Exiqon).
RNA library preparation protocol:	3 ul of total RNA was processed by reverse transcriptase and mixed with TaqMan OpenArray Real-Time PCR Master mix (1:1).

Reference

PMID:	30396857
Title:	Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsy
Author:	Raoof R, Bauer S, El Naggar H, Connolly NMC, Brennan GP, Brindley E, Hill T, McArdle H, Spain E, Forster RJ, Prehn JHM, Hamer H, Delanty N, Rosenow F, Mooney C, Henshall DC
Journal:	EBioMedicine. 2018 Dec;38:127-141.
Description:	Using a case-control design, we collected plasma samples from video-electroencephalogram-monitored adult TLE patients at epilepsy specialist centers in two countries, performed genome-wide PCR-based and RNA sequencing during the discovery phase and validated findings in a large (>) cohort of samples that included patients with psychogenic non-epileptic seizures (PNES)